ID A0A3Q3FYR2_9LABR Unreviewed; 911 AA.
AC A0A3Q3FYR2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK2 {ECO:0000313|Ensembl:ENSLBEP00000025362.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000025362.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000025362.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. GRIK2 subfamily. {ECO:0000256|ARBA:ARBA00038119}.
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DR AlphaFoldDB; A0A3Q3FYR2; -.
DR STRING; 56723.ENSLBEP00000025362; -.
DR Ensembl; ENSLBET00000026650.1; ENSLBEP00000025362.1; ENSLBEG00000019353.1.
DR GeneTree; ENSGT00940000155610; -.
DR InParanoid; A0A3Q3FYR2; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF38; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 566..585
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 642..664
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 823..847
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 435..804
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 445..510
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 911 AA; 103030 MW; 695542312D9A0AB6 CRC64;
MKITSHHLMI TSLVFRSNLR LIPLLLLFLG YSRGMPHVLR FGGIFESIES GPSGAEELAF
KFALNTINRN RTLLPNTTLT YDIQRINIFD SFEASRKACD QLSLGVAAIF GPSHSSSANA
VQSICNALGV PHIQTKWKHQ VSDNRDSYYV SLFPDFSSLS RAILDLVHFF KWRTVTVVYD
DSTGLIRLQE LIKAPSRYNI RLKIRQLPTE TKDAKPLLKE MKKAKEFHVI FDCGHEMAAW
ILKQALAMGM MTEYYHYIFT TLDLFALDME PYRYSGVNMT GFRILNTENS QVSSIIEKWS
MERLQAPPKP DSGLLDGFMT TDAALMYDAV HVVAVAVQQS QQITVSSLQC NRHKPWRFGG
RFISLIKEAH WDGLTGRVLF NKTNGLRTDF DLDVISLKEE GLEKIGTWDP PSGLNMSDNH
KSKTSNITDS LANKSLRVST ILEEPYVMFK KSDKPLYGND RFEGYCIDLL RELSGILGFR
YEVRLVEDGK YGALDEGTGQ WNGMVRELMD HKADLAVAPL AITYVREKVI DFSKPFMTLG
ISILYRKPNG TNPGVFSFLN PLSPDIWMYI LLACLGVSCV LFVIARFSPY EWYNPHPCNP
DSDVVENNFT LLNSFWFGVG ALMQQGSELM PKALSTRIVG GIWWFFTLII ISSYTANLAA
FLTVERMESP IDSADDLAKQ TKILYGVVED GATMTFFKKT KISTYDKMWE FMNSRRQSVM
VKNIEDGIQR VLTSDYAFLM ESTTIEFVTQ RNCNLTQIGG LIDSKAYGVG TPMGSPYRDK
ITIAILQLQE EGKLHMMKEK WWRGNGCPEE ESKEASALGV QNIGGIFIVL AAGLVLSVFV
AVGEVLYKSK QNAQLEKRSF CSAMMDELRV SLKCQRRLKQ KPQPPVIVKT EEVINMHTFN
DRRLPGKETM A
//
