ID A0A3Q3G0C7_9LABR Unreviewed; 2473 AA.
AC A0A3Q3G0C7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000024538.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000024538.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR STRING; 56723.ENSLBEP00000024538; -.
DR Ensembl; ENSLBET00000025802.1; ENSLBEP00000024538.1; ENSLBEG00000018699.1.
DR GeneTree; ENSGT00390000010427; -.
DR InParanoid; A0A3Q3G0C7; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 2062..2242
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 127..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2271..2303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2419..2473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2284..2299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2429..2452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2473 AA; 280383 MW; EDDC61EBAA1CFECA CRC64;
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTAKSL LYNGRISDEV SSLLVCRDEN
LVTQLAQSLN QVSTEHIELK DNLGNDEPEG EMPMLLQTLL SRNPKIFRDK SMQTHYHQPL
IQQYKVSQTQ VHGSPGSNYQ HTTVPQSPSG CFTSQQSGSG TRFVTQQSSP IPSPYTPQSP
ADYMQYNPPS YSQHQQTQQG EQSQEKFASV VRNIHHNKVS GQLSSNSSHH NAELGSDEDY
MNMAHRLGHE NDPSMRASKF PVKSPQSVCS PAGSEEAVKR SRRTLIMESP QPDTPPGTAP
DLLLTSSDRK RKQKEKIKEE NKQIDNNASY GIVSSPLKDS ARLTLKLTRV KSPNMDPSHI
NLHETDSMNN NNQLSRTTLD LTHKLGAEEQ ENCQQVHVQQ NSKEIGVIGG DVFDDAEIDT
LVEIDRIERE SASERERWSK EVQDKDKPLK KRKQDSYPLE SGAEPTDGPT VTGDNTDSKL
TPKKTNAASN GSSRPALMVS IDLQQAGRLV RQPVVVLEPQ QLCEDHLKRI KLKTDGKVDT
VVETRPEIIK QHVDKPKKTG SDGQPETPKQ KQDGRRESKH RHDGKTDSSK GHSDDRRPDT
PRQRHEKLSD SGHKEEKNHI SHRSNVTQTK IPKTTKEVER NSRQEEDRTR DKDKDREKVS
DKDRDMDKNR EKDRDRVKER AKDKDRDKDK ERKRDKDRDK NRDKERDRDK DRERKIKTLS
SENCKRHSPD LNNKPDSARI KQDGSRKSND LNGRQRTDGS SLQNAHHKDE MKSGEGQVSC
QAGSKQQSME TKASEFPSYL LGDKKGSLKN FVIPKLSRDG KDSQHPSKVK DVFSESHLSK
VKDVFSESHP SKVKDNLSKA AKPVVVVKKL SIDEVKTIIK ESRNAQRSRN WSSSDKSGRV
SVTVTVTATR KKHKKHHDKT WKGEEKRGSG DHRHHNARRG SGGRHRDSDN SDGGSPPTNL
SDDFNKFDMN SHLTNIYVDI PLTEIMDSST FKRFTASVDN ILESLDDVDL TNADDDDEIP
EELLLGKHQL SELGSDSAKM KAMGAFNKFP SEKLVKILNI LEKNIQDSVK LSTLMNHGND
SMDEERLWRD LIMERVTKSA DACLTALNIM TSPKMPKAVY IEDVIERVLQ YTKFHLQNSL
YPQYDPVYRV GPHGGGLHTS KSKRAKTSTH KQKVVVMLYN KVCDIVSNMA ELLEIQLLTD
TTILQVSTLG ITPFFVENVS ELQLCAITLV TAVFSRYEKH RQLILEEVFT SLARLPTSKR
SLRNFRLNSS DSDGEPLYIQ MVTALVFQLI QCVVNFPERD SDDEHSKKVD RDVLITNSYE
TAMRTAQNFL SVFLKKCGSK QGEEDYRPLF ENFVHDLLST VNKPEWPAAE LLLSLLGRLL
VHQFSNKQTE MALRVASLDY LGTVASRLRK DAVTSKMDQK AVDRILRESP GDDETQQLQK
ALLDYLDENI ETDPALVFAR RFYIAQWYRD TTSEAEKAIK SQNDDEDVRG RHYSHDVDST
AEIMQKAETR KKFLRKIIRT HPSQFRSLKL NSDTVDYEDS CLIVRYLASM RPFSQSFDIY
LSQILRVLGE SAIAVRTKAM KCLSEVVAVD PSILGRLDMQ RGVHCRLMDN STSVREAAVE
LLGRFVLSRP ELIEQYYDML IERILDTGIS VRKRVIKILR DICLEQPDFH KITEMCVRMI
RRVNDEEGIK KLVNETFQKL WFTPTPGHDK DAMTRKILNI TDVVSACKDT GYDWFEQLLT
NLLKSEEQAS YKPAKKACVQ LVDNLVEHIL KHEESLADCE DKGVNSGRLV SCITTLFLFS
KIRAHLMVKH AMTMQPYLTT KCNTQNDFMV ICNVAKILEL VVPLMEHPSE TFLTTIEEDL
MKLIIKHGMT VVQHCVSCLG AVVNKVTHNY KFVWACFNRY YGALAKLKTQ HQEDPNSSTL
ATNKPTLLRS LFTVGALCRH FDFDQEEFKG ASKIIIKDKV LELLLYFTTH EDEEVQIKAI
IGLGFQFIMH PELMFVQDVK VLYNGNLSDE SSSVNLKIQV LKNLQCYLQE EDSRMQEADR
EWKKQAKQED LKELGDVASG MSSSIMQIYL KQVLESFFHS QSTVRHFALS VITLTLNQGL
IHPVQCVPYL IAMGTDPEPT MKNKADQQLV EIDKKYSGFI HMKAVAGLKM SYQVQQAING
SKGKVVRGFR PEDSDAALCS HLYSLVRGNR QHRRAFLISL LNLFDDSSKT EVNMLLFIAD
NLACFPYQTQ EEPLFIMHHV DITLSVSGSN LLQSFKEVRS FVCVKIKISS SSSSSSSSSS
SSEEEVVVEK KKKSGAADSD SDLDDEEAVM LRLPENPVPL LDFASASQGI LLLLVLKQHL
KNLYGFSDSK IQKYSPTESA KVYDKTVNRK SKVHFNPRQT LEYLKSDLSN MELSRDTKRN
IVKQYLDFKV LMEHLDREEE DEQGEASANA RNKAITSLLK GPKSLNHNHN NHAAPVESDD
EESEDEEPPV VRI
//
