ID A0A3Q3G2S7_9LABR Unreviewed; 1375 AA.
AC A0A3Q3G2S7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRG {ECO:0000313|Ensembl:ENSLBEP00000025979.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000025979.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000025979.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 5 subfamily. {ECO:0000256|ARBA:ARBA00006246}.
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DR STRING; 56723.ENSLBEP00000025979; -.
DR Ensembl; ENSLBET00000027271.1; ENSLBEP00000025979.1; ENSLBEG00000019629.1.
DR GeneTree; ENSGT00940000155048; -.
DR InParanoid; A0A3Q3G2S7; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd03122; alpha_CARP_receptor_like; 1.
DR CDD; cd00063; FN3; 1.
DR CDD; cd17670; R-PTP-G-2; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR041887; Alpha_CARP_receptor-type.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF449; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 696..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..286
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT DOMAIN 314..413
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 778..1049
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 969..1040
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1080..1340
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1257..1331
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 497..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1375 AA; 155037 MW; FB4001114C59178A CRC64;
MLKWLSCHFL PTNVYVFHKL LFFSISAGSH GPRGWDASYP ECGAKNQSPV NIADEQTLVS
EEYQELVLEK FTAESSNQTT MKNTGKTVAV LLKDDYFVRG AGLPGRFKAE KMEFHWGQSN
GSAGSEHSIN GRRFPVEMQI YLYNSDDFDS LSAAIKERRI IAAMAVFFEV KYNQDNPAVE
PIIQGLKGVV HHEKETHLRS FILRDLLPSS VDSYYRYTGS LTTPPCSKVV EWIIFSRPVY
LSHSQLEFFY HIFTTEQQDH VKSVDYLRNN FRHLQNLDNR KVYKSAVKDA WQRDLTEIME
SPHGTESSRV CSSAPVSMKI KPLNQTALMV SWERPLTDYH PPITSYMVSY SWVKRDVADE
KTFTKTGDQS MKAVITNVSP DVLYLFRVQA VCQHDLRSDF SQTLLFRANT TRIFEGSRIV
KTGMPTISPA SSADMAPISS GSSTWTSSGI HFSIVSMATG MGPSSSGSQA TVASVVTSTL
LAGLGVSGGV LSSLPSSAWP TQAPKATQNP TRPSAPPEKS STEQAPPRAS ETDAPSEESK
AKREGEGSEK EEEEEGEGEQ EEGEDEKKTK SKTGAHNEEK QANSTVANEP FIPTPASTAK
EKGEGNSTVR GSTAPESTAD DQLVNVENNH TDINAVSTQE PRNDSAEMQI PQSSTLSPKI
NRDDKSNWPF SVHTGELTSH SFTDIHPQQG MGRMVWIVPL VVVSALTLLC LIMLLIVMVY
WRRFFQTAHF YVEESSSPRV VANENIPVIP IPDDMEAIPV KHFVKHIMEL YKNNLQGFSE
EFEEVQRSTA DLKITAEHSN HPDNKHKNRY INIVAYDHSR VKLRALAGKD AKHSDYMNAN
YVDGYNRPRA YIAAQGPLKS TFEDFWRMVW EQNTGIIIMI TNLVEKGRRK CDQYWPMENS
EQYGNIVVTL KSTKVHACYT HRRFHIRNTK VKKGQKGNPK WKLNERIVVQ YHYTQWPDMG
VPEYTLPVLT FINRSSAART ADMGPVLVHC SAGVGRTGTY IVIDSMLQQI KDKSTVSVLD
FLKHIRTQRN YLVQTEEQYV FIHDALMEDI LSRETEVPAW QLHSYVNSIL TPNSAGRTQL
EKQFRLLTQC NTRFVECFSA HKDSNKEKNR NSSVVPSERA RVGLTTLPGM KGTDYINASY
IMGYFRSNEF IITQHPLPHT TTDFWRMIWD HNAQIIVMLP DNLGLAEDEF VYWPSREEAM
NCIAFTVTLI SKDRLCLSNE EQIIIHDFIL EATQDDYVLE VRHFQCPKWP NPDAPLSSAF
ELISVIKEEA MTRDGPTIVH DEYGAVSAGM LCALTTLSQQ LENEGVVDIY QVAKMINLMR
PGVFTDIEQY QYLYKAMLSL VGNRECSLSP MHMDTNGVVV IADESDPAES MESLV
//
