ID A0A3Q3G3Q0_KRYMA Unreviewed; 1568 AA.
AC A0A3Q3G3Q0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSKMAP00000018887.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000018887.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000018887.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR RefSeq; XP_017286792.1; XM_017431303.1.
DR STRING; 37003.ENSKMAP00000018887; -.
DR Ensembl; ENSKMAT00000019147.1; ENSKMAP00000018887.1; ENSKMAG00000013994.1.
DR GeneID; 108244808; -.
DR KEGG; kmr:108244808; -.
DR CTD; 5727; -.
DR GeneTree; ENSGT00940000159011; -.
DR OMA; HLYDTEW; -.
DR OrthoDB; 1219406at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 429..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..853
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1112..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1139..1161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1168..1194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1238..1263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 428..588
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..653
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1379..1415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1568 AA; 173559 MW; 4DC8600299420D62 CRC64;
MASAANAPSE QDNGDPDRPR ITRRSRGDYA RSTPLDLEYL QRPSYCDAGF ALEQISEGKA
TGRKAPLWLR AKFQTLLFRL GCYIQKNCGK FLVVGLMIFG AFAVGLRAAN LETDVEKLWV
EVGGRVNQEL RYTRQKMGEE AMFNPQLMIQ TPREDGANVL TVEALLQHLE SALRASRVHV
YLYNRQWKLE HLCYKSGELV TETHLMNQII EKLHPCLIIT PLDCFWEGAK LHSGMVYLPG
EGSKQWTNFD PKEFLNKLDK RGLNVEGFEV MLEKAGVGHG YMDRPCLNPA DPDCPLTAPN
KNSTKPFNMA GTLSGGCHGL SRKYMHWQEE LIVGGTTKNG SGPLLNAQAL QTMFQLMTPK
QMFEHFRGYD EVSHINWNEE KAAAILEAWQ RRYSEAVLQS VAANSSQIVL PFTTTTLEDI
LKSFSDISVI RVASGYLLML AYACLTMLRW DCAKSQGAVG LAGVLLVTLS VAAGLGLCSL
LGISFNAATT QVLPFLALGV GVDDVFLLAH AFSETGQNKR IPFEDRTGEC LKRTGASVAL
TSISNVTAFF MAALIPIPAL RAFSLQAAVV VVFNFAMVLL IFPAILSMDL YRREERRFDI
FCCFYSPCAN RVIQMEPQAY LDGADAGRYS PPPSYRTPPP SYHTPPPSYS SPPPSYSSHS
FAQQTQITMQ STVQLRTEYD PRTQAFYTTA EPRSQISVQP INPAPTRGNH SNDFYNNNNI
NSSMNSSGSN HGNLSNNNNS SRGNGGSRGS APFSHQYPAP SAAPPTSSVF SIPQGDTASS
TGQSPENNSS TRDLLSHLGE ASLGFRCLEP SCSRWTLASF AEKHYAPFLL QPTTKVVVIM
IFLCLLGISL YGTTQVRDGL ELTDIVPRET SEYDFIGAQF KFFSFYNMYV VTQRADYAQN
QPLLHQLHQR FHSIRYVLKE DDGQLPLMWL HYFRDWLQGL QQAFDKDWEA GRITTNSYKN
ASDDGVLAYK LLVQTGRREK PINFNQLTRQ RLVDADGIIN PGAFYIYLTA WVSNDPVAYA
ASQANIRPHP PEWLHDRTDS MPETRLSIPA AEPIEYAQFP FYLNGLRETP QFVEAIESVR
AICNNYSRQG LPSYPNGYPF LFWEQYVSLR HWLLLSISVV LACTFLVCGL FLLNPWTAGI
IVLVLSLMTV ELFGFMGLMG IKLSAVPVVI LIASVGIGVE FTVHVALAFL TAIGDRHKRA
VLALEHMFAP VLDGAFSTLL GVLMLAGSEF DFIVRYFFAV LAILTVLGVL NGLVLLPVLL
SYFGPYPEVS PVDGRSRLPT PTPEAPPRVV HFSVRPHQTA GATTTSGAAT DSSDSEYSSN
TTASGISQEG QNYNLHSHRG QTQAEEQQYH LRTSRARGAR MEEERREGAG HRHSPRQPEP
PSYTVSSSYP SQGCDSGPQH GTTQRNSSRN LRSQLHRQVP PPARPRTDAF EMSTEAGGHH
GLQGPREHSA GHRGHSSHNP QPHHHLPHQH PSNTPFCQPI TTVTASASVT VAVHPASFST
QNPASSYPEY PAADSYCPSG PEEPEAPFQD PHVPVYTHAE ARDVKVEAME LQDLELEAAE
SNSGRRAS
//