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Database: UniProt
Entry: A0A3Q3G4H4_KRYMA
LinkDB: A0A3Q3G4H4_KRYMA
Original site: A0A3Q3G4H4_KRYMA 
ID   A0A3Q3G4H4_KRYMA        Unreviewed;      1170 AA.
AC   A0A3Q3G4H4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE            Short=PARP {ECO:0000256|RuleBase:RU362114};
DE            EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000019152.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000019152.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-
CC         ribosyl)n+1-acceptor + H(+).; EC=2.4.2.30;
CC         Evidence={ECO:0000256|ARBA:ARBA00033987};
CC   -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC       {ECO:0000256|ARBA:ARBA00024347}.
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DR   AlphaFoldDB; A0A3Q3G4H4; -.
DR   Ensembl; ENSKMAT00000019415.1; ENSKMAP00000019152.1; ENSKMAG00000014133.1.
DR   GeneTree; ENSGT00940000156161; -.
DR   OMA; VFSQYNI; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd09524; SAM_tankyrase1_2; 1.
DR   CDD; cd01438; tankyrase_like; 1.
DR   Gene3D; 3.90.228.10; -; 1.
DR   Gene3D; 6.20.320.10; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 5.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR24189; MYOTROPHIN; 1.
DR   PANTHER; PTHR24189:SF50; MYOTROPHIN; 1.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF12796; Ank_2; 6.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF00644; PARP; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 17.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF56399; ADP-ribosylation; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 3.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 15.
DR   PROSITE; PS50088; ANK_REPEAT; 15.
DR   PROSITE; PS51059; PARP_CATALYTIC; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU362114}; NAD {ECO:0000256|RuleBase:RU362114};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|RuleBase:RU362114}.
FT   REPEAT          54..86
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          87..119
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          120..152
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          207..239
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          240..272
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          273..305
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          360..395
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          396..428
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          429..461
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          522..554
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          555..587
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          588..620
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          675..707
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          708..740
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          741..773
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          873..932
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          955..1160
FT                   /note="PARP catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51059"
SQ   SEQUENCE   1170 AA;  126631 MW;  6D0B99D52607701E CRC64;
     NGDASSLLSA AAAAELPAVL PTPELFEACR NGDVSRVKKL VDAVNVNAKD MAGRKSTPLH
     FAAGFGRKDV VDHLLQTGAN VHARDDGGLI PLHNACSFGH SEVVSSLLCQ GADPNARDNW
     NYTPLHEAAI KGKIDVCIVL LQHGADPNIR NTDGKSALDL AEPSAKAVLT GEYKKDELLE
     AARSGNEEKL MALLTPLNVN CHASDGRKST PLHLAAGYNR VRIVQLLLQH GADVHAKDKG
     GLVPLHNACS YGHYEVTELL LKHGACVNAM DLWQFTPLHE AASKNRVEVC SLLLSHGADP
     TLLNCHSKSS VDMAPTPELK ERLTYEFKGH SLLQAAREAD MAKAKKTLAL EIINFKHPHT
     HETALHCAVA SPHPKRKQVT ELLLRKGANV NEKNKDFMTP LHVAAERAHN DIMEVLQKHG
     AKVNALDTLG QTALHRAALA GHLQTCRLLL GYGADASLVS LQGFTAAQMG NEAVQQILNE
     NVPVRNSDVD YRLLEAAKAG DLDTVKSLCT AQNVNCRDLE GRHSTPLHFA AGYNRVSVVE
     YLLHHGADVH AKDKGGLVPL HNACSYGHYE VAELLVRHGA SVNVADLWKF TPLHEAAAKG
     KYEICKLLLK HGADPTKKNR DGNTPLDLVK DGDTDIQDLL RGDAALLDAA KKGCLARVQK
     LCSPDNINCR DTQGRNSTPL HLAAGYNNLE VAEYLLEHGA DVNAQDKGGL IPLHNAASYG
     HVDIAALLIK YNTCVNATDK WAFTPLHEAA QKGRTQLCAL LLAHGADPTM KNQEGQTPLD
     LATADDIRAL LIDAMPPDAL PSCLKPQVSA NVVSTGAAGG VVISPSPSPS CLSAASSIDN
     LNTPLGDITV GGASGIADGA SGSDRKEALL DMTINQFLKS LGLEHLRDIF QREQISLDVL
     ADMGHEELKE IGINAYGHRH KLIKGIERLL GGQQGGNPYL TFHCSSQGTV LIDLAPDDKE
     FQSVEQELQS TIREHRDGGN AGGVFSRYNI IKIQKVVNKK LRERYSHRQK EIADENHNHH
     NERMLFHGSP FINAIIHKGF DERHAYIGGM FGAGIYFAEN SSKSNQYVYG IGGGTGCPPH
     KDRSCYVCHR QMLFCRVTLG KSFLQFSAMK MAHAPPGHHS VIGRPSVNGL AYAEYVIYRG
     EQAYPEYLIT YQIMKPESQA APAASAEQKS
//
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