ID A0A3Q3G5P4_KRYMA Unreviewed; 180 AA.
AC A0A3Q3G5P4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial {ECO:0000256|ARBA:ARBA00020530, ECO:0000256|PIRNR:PIRNR009288};
DE AltName: Full=Complex I-ASHI {ECO:0000256|ARBA:ARBA00032752, ECO:0000256|PIRNR:PIRNR009288};
DE AltName: Full=NADH-ubiquinone oxidoreductase ASHI subunit {ECO:0000256|ARBA:ARBA00032699, ECO:0000256|PIRNR:PIRNR009288};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000019512.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000019512.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|PIRNR:PIRNR009288}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|ARBA:ARBA00011533, ECO:0000256|PIRNR:PIRNR009288}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004298}; Matrix side
CC {ECO:0000256|ARBA:ARBA00004298}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB8 subunit family.
CC {ECO:0000256|ARBA:ARBA00008039, ECO:0000256|PIRNR:PIRNR009288}.
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DR AlphaFoldDB; A0A3Q3G5P4; -.
DR Ensembl; ENSKMAT00000019775.1; ENSKMAP00000019512.1; ENSKMAG00000014386.1.
DR GeneTree; ENSGT00390000000628; -.
DR OMA; PRYKNSY; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:UniProtKB-UniRule.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:UniProtKB-UniRule.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:UniProtKB-UniRule.
DR InterPro; IPR008699; NDUFB8.
DR InterPro; IPR016551; Ndufb8_metazoa.
DR PANTHER; PTHR12840:SF1; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12840; NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT; 1.
DR Pfam; PF05821; NDUF_B8; 1.
DR PIRSF; PIRSF009288; NDUB8; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|PIRNR:PIRNR009288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR009288};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR009288};
KW Mitochondrion inner membrane {ECO:0000256|PIRNR:PIRNR009288};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Respiratory chain {ECO:0000256|PIRNR:PIRNR009288};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR009288}.
FT TRANSMEM 118..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 180 AA; 21281 MW; 346BAD93F2FD2AF8 CRC64;
YEELKNGKWL TDLAYFLSAL QHSSGMSKDM IPGPYPKTPE ERAAAAKKYN LRVEDYEPYP
DNGEGFGDYP KLPDKSQHER DPWYNWDHPD LRRNWGEPIH WDFDMLTRNR VDMSPSPVSW
SSMCKQLFGF IGFMLFMFYL GEKFPSYQPV APKQYPYNDL YLERGGDPEK QPEEVKNYEI
//
