ID A0A3Q3G5T9_9LABR Unreviewed; 1703 AA.
AC A0A3Q3G5T9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSLBEP00000026333.1};
GN Name=ARAP3 {ECO:0000313|Ensembl:ENSLBEP00000026333.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000026333.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000026333.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 56723.ENSLBEP00000026333; -.
DR Ensembl; ENSLBET00000027629.1; ENSLBEP00000026333.1; ENSLBEG00000019875.1.
DR GeneTree; ENSGT00940000158869; -.
DR InParanoid; A0A3Q3G5T9; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd17228; RA_ARAP3; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 4.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 14..73
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 438..530
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 545..634
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 631..765
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 854..959
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 970..1068
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1072..1253
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1282..1376
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 79..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1665..1703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1703 AA; 192623 MW; CDFAE529D0EE34FE CRC64;
MLVVMATLDG STPVEKLLSV IHLERYLDSF HRAGLLLAKD FTHLDHEALV SLGITATGHR
KRILRLVVYI QRTEAQRANQ KVDLPRDRCQ SVSGSSSSER VPSTALLGES SGPVNFEAFR
NSSAPNLRAM LTNDSPRPVL KPIPKPRTVF NRRRTTPVHF CPTPDPAPPP PRRLSQDSIC
FTVLEGLTSG DTAAPEHLKS TSDRDIESSL SGRMPSQAER RKPSRSFSLS DTGRLLPPVP
PRLNRGALPA TSQGSPPSSS SSSPIRTEQV NHISPMTSCP GSADSSRLSG SSGGSPRGGG
LEMVSNEIYW GTLPGSTAPA GVRRYCSQQS HPPRSGTLFT PIVCSTASTD DPEEEISPYC
ETVFQTRRNP LILEFSWTKR LSQALHPGDS QGYSTVGEPP LPPLHSLSLP AHTFLSEGDE
DLTISPYASY TSLTERAPPI ISGWLDKLSP QGNYVFQKRY VKFDGKNLMY FGSEKDVYPK
GVIPLAAIQM ARPAKDNKFE IVTSHRIFVF KADNEVLKRR WVGTLQEHVR DQLVFGRRRF
GPGSHCQKHG VLELKGTKSK VYAAIMTDQI WLYKSEQCFR NGIGITVIEA RGSTIRDGKH
KSFELITPYK NFSFTSESER EKRYWMEALQ ESIAETLSDY EVAEKIWSNR SNRMCADCKA
LNPDWASINL CVVICKNCAG QHRGLGTMVS KVQSLKLDTS VWSNEIVQLF IMLGNDRANE
FWGAGLSPWE EMDCDASPEQ RREFITQKYK EGRFRLKHPT ISSQDELLKV LCSAVSEQIL
LKTVTQIFSE AESARLANDS NGCQRHLQQL NHCTPSGISA PIYCNLLQPH LIYTVSGGTR
AVFIPRLYDE IMQPVLHSGY LYKSDFFLSD FQKFWCSVDQ SLLLYESDRS ADPCMQISVK
DIVCLGVSRP DSSHSSNGFI DRFRYTFELY LTSDKLHQFG LETADTLHSW TRSIGKATTP
LSCHCLLTRE FERVGLLRYR AMLDAQHWKE AFFVLQKSNL FICPRNDGAA EDIINLNRLQ
ELSITSETEN HEKKDILVLV ERGRTLHLQG VGRTDFTLWY SDIQRAAGGK GNTLREQQLS
RNDIPIIVDS CIAFITQYGL GHEGIYRKNG AKSRIKLLME EFRKDARNVK LRIGDHFIED
VTDVLKRFFR EVDDPVFMCD LHPLWQEAAK IPQRSLRLDR YKEIIRTLPR VNRTTLAALI
SHLYRVQKCA DLNQMCTKNL SLLFAPSLFQ TDGKGEHEVK IVEDLIDNYL YVFDIDEEHQ
TQIELEISLI TTWKDTQLSQ AGDLIIEVYL EMKIPDCCIT LKVSPTMCAE ELTNQVLFMR
NVPATDRDVW MTFEAIEEGQ LERPLHPKEK VLEQALQWCK MADPSSAYLV VKRVPKGEGI
NILTSYKSEI MKVGLLKCRE EPPKLLQGNR FQERTFQIKE HKLLLKDKKS IKPEKEWALK
SMKIYIGIRR KLKAPTRFLC CTSEADLWDW ITSFLKAQNE DPGPPVLRRH SSSDISKQKF
GTMPLVPIRG DESNSSLLSA NQTLRKLHDR RTLSMYFPMK VQQDSLEERP ESPDLPEPLY
EEVGDFGLQV LKSLETSFLS SSTSETQEVL DQPPLRLVPL ETGHIDHIIV PEPVLTDGGC
VDSEEQRGGG DGGADCQQLA MRRRRRRSQL TGVCTPSQEL LLQELSSAFN RRTEEGEGEE
VQEIQEERNQ DDQEEKEEKP YDV
//
