ID A0A3Q3G7F1_9LABR Unreviewed; 394 AA.
AC A0A3Q3G7F1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Vascular endothelial growth factor C {ECO:0000313|Ensembl:ENSLBEP00000026898.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000026898.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000026898.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|RuleBase:RU003818}.
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DR AlphaFoldDB; A0A3Q3G7F1; -.
DR STRING; 56723.ENSLBEP00000026898; -.
DR Ensembl; ENSLBET00000028197.1; ENSLBEP00000026898.1; ENSLBEG00000020429.1.
DR GeneTree; ENSGT00940000156167; -.
DR InParanoid; A0A3Q3G7F1; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0061026; P:cardiac muscle tissue regeneration; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:1900746; P:regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR GO; GO:0048845; P:venous blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0060855; P:venous endothelial cell migration involved in lymph vessel development; IEA:Ensembl.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR004153; CXCXC_repeat.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR PANTHER; PTHR12025:SF3; VASCULAR ENDOTHELIAL GROWTH FACTOR C; 1.
DR Pfam; PF03128; CXCXC; 2.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU003818};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 115..214
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT REGION 82..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 394 AA; 44221 MW; A457E4D8CDC555DB CRC64;
MLQALLRLYF KSDSSVFSLS LKISPFMIIS EGVSGLFQDS PPKPDMEEKL RSASSVDELM
SLIYPSYWAS LKCRSKLSAA ASSASKLSPR PQPRRQRPPA ETEEPTFAAA YLNLDLLKSI
ELEWRKTQCM PREVCVDVGR EFGAPTNIFY KPPCVSVYRC GGCCHSEDKQ CRNISTGYLS
KTLFEITVPI TQGTKPVTIS VANHTQCSCL SKLDVYKQVH SIIRRALPEC PIANRTCSPG
QTWSSGQCRC VSITADVCGP DKELDVETCQ CVCQHRDQTQ DCGPHRHLDR NTCKCVCNIS
PPLSCPLNHV FNKDTCQCAC IKTCPRHQPL NKAKCSCECN ESPNKCFLKG RRFHPATCSC
LRPPCEVRRR RCEPGFSFSE EVCRCVPSHW RRLD
//
