ID   A0A3Q3G9Y2_9LABR        Unreviewed;      1080 AA.
AC   A0A3Q3G9Y2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-1-like {ECO:0000313|Ensembl:ENSLBEP00000029732.1};
GN   Name=CACNA2D1 {ECO:0000313|Ensembl:ENSLBEP00000029732.1};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000029732.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000029732.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC       family. {ECO:0000256|ARBA:ARBA00007060}.
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DR   AlphaFoldDB; A0A3Q3G9Y2; -.
DR   Ensembl; ENSLBET00000031132.1; ENSLBEP00000029732.1; ENSLBEG00000022452.1.
DR   GeneTree; ENSGT00940000155209; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   CDD; cd12912; PDC2_MCP_like; 1.
DR   CDD; cd01463; vWA_VGCC_like; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   PANTHER; PTHR10166:SF6; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1080
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018590584"
FT   DOMAIN          249..426
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   COILED          70..104
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1080 AA;  122736 MW;  A613069F055DA3B4 CRC64;
     MDTCRVRAWV FLLLFWQDGS LASQFPTQLM IKEWVDQMQK ELVTLADTAT AGKSLTQIFL
     SNQNLYTVEQ NDAEELVARA ATKIEQLLRK RSAALEKLAT AAENFQMEHQ WRDEFEDDEI
     GYYNAKDNLD ANETEGRKYR IRPDFKEDSL FRRLTDHNHT AVHIPTDIYD GSTIVLNELN
     WTEALEDVFR KNREDDPTLL WQVFGSATGL ARYYPASPWM DARKTPSKID LYDVRRRPWY
     IQGASSPKDI LILVDASGSV SGLTLKLIKT SVSEMLETLS DDDYVNVVYF NTRVKKTACF
     EHLVQANVRN KKLLKDAVQN ITAKGITNYT KGFEFAFEQL SVMNVSRANC NKIIMLFTDG
     GEERAQAILE KYNADKKVRI FTFSVGQHNY DKGPIQWMAC SNKGYFYEIP SIGAIRINTQ
     EYLDVLGRPM VLADQQAKQV QWTNVYLDAL ELGLVITGTL PVFNKTKTRD DKNGEYQNQL
     ILGVMGIDVS LGDIKKLTPR FTIGPNGYYF AIDPNGYVLL HPNLQPKNPK FQEPVTLDFL
     DAELENDIKV EIRRMMIDGE TGERTIDTLV KTQDERYIDR GVRTYTWAPV NGTDYSLALA
     LPKYSEHFIQ AKLGDDMREA MCEKAMDTIQ LERFEEFGYT YIAPREYCKE LKLSPNNTQF
     LLDFSQYIDR NTPNACNVSM VSRLILDAGL TAELVKLWNE QTVDGILARF VATDGGITRV
     YPKSAGEEWT ENSETYESSF YKRTLDNEIY IFTAPSFNPE SREPVSESGI LVSKAVEVTI
     NEVTLKPAVV GVKLNVSFWM NSFMNATLKL NCKDEICGCL RNDKHVDCVI LDDGGFLLIS
     NQDEYINLIG QFFGEVDPVL MINLVNTSLY SFNKTYDYQS VCDPEKDSKA AAGPRSVYVP
     TIADLLSIGW WASSAAWSIL QQLFFGIIFP NLLDAAETAE EDVPDTMFKE SCITEQTQYF
     FDNDERSYSG VLDCGNCSRM YRAEKLPHTN LVFLITDAKA TCLSCDPRPL RQAEQPSEGP
     DPCELAQNPR YRKGPDVCFD NNDNEDDSDC GGGTCLSPCL WPMLGLQLLL LWHFTSLQHL
//