ID A0A3Q3GA85_KRYMA Unreviewed; 2316 AA.
AC A0A3Q3GA85;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Polycystin 1 like 1, transient receptor potential channel interacting {ECO:0000313|Ensembl:ENSKMAP00000020937.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000020937.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000020937.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR STRING; 37003.ENSKMAP00000020937; -.
DR Ensembl; ENSKMAT00000021211.1; ENSKMAP00000020937.1; ENSKMAG00000015499.1.
DR GeneTree; ENSGT00940000162104; -.
DR OMA; MAVTAYH; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR46730:SF4; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 1; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR Pfam; PF00801; PKD; 2.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00308; LH2; 1.
DR SMART; SM00089; PKD; 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50093; PKD; 2.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1530..1549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1736..1754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1766..1795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1915..1937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1949..1969
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2048..2065
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 329..369
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 412..466
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 471..946
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1575..1695
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 773..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1159..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1807..1828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1850..1889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1808..1828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1852..1876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2316 AA; 256097 MW; C8E7B64B32ECBE48 CRC64;
MWRLQVAVGP VVADLTLNIC DNQLTATDDV SAELLRLTLQ AECNAEGDCN HGNVTNRHRR
GSILSHLDAH HPLRASDPSS CHLLLRLHLR LPSAGGQSPE LTTEEWTITV SPPNSGLYSV
TVRVFSPVRR SRVLLQEPAG DVLQDDPRGI AAKQQCSVSL RVAAGSNVTV SPVAAELHRN
SSCLAGAEAT AVLLSSHIRE VVIELRAENR ASSQSKSVRM CVEGKRKPQD QIHSSWQPLT
CQSPTYSKED KGKEAKNTIK ISSQVVKIYK NLIYNQSNHD YFQKEGFSSL SCYTLTLKSP
FYFAVVRICA TKQVQPTNTD ITFVAVADTA HPAELFWDFG DSRSARTSSR IITKRYQNPG
SYDVVVAASW GQAVVVSDVF AVLVQRAVEL SRLVHRASVL KNQTVTVSCR VNAGTDLTFA
WSFGDGATRS GQRTVRHVFN RTGEFTIKVV VSNLISSASL SSLIFVVDRP CQPPPVKNMG
PLRLQVWRFE VVRLGVTFES DVECDVSGGL RYSWTLLDSA GRDVPLPLGD KQKQILVLPS
HALQYNTYTA TARVQVFGSV VYSNYTVRLQ VMPSPPVALI QGGTNIFINK KNTELISLNG
RASYDPDFPQ NPLSYSWTCK PVSAITTSCY NQDVPTSSPE LQFPISLLKD SFDQFQFRLT
VHSGERSSSS ETFLTVTPDP TGTVSVHCDQ CRGDGANWDQ PFSVAAACAD CEEPVQFTWS
LYLVNASSKT ASEGKRDEEP RAEGRSVSGD LLNILRDKKY HLGTLFPCFP SDLSNSEPST
SPRLHSDPTD LSPQTSDFLS DSDSSADWEE YFPLLESPDA YDAPFPAEEG DPGMSAGRPS
GSWRRLGDSG ANSARPSPSP DRQRISSSLL RFKPFSLKPK TQYLLEVTAK SRQSFLGRTQ
LFVKTSPAPE GVTCQVQPAE GAELHTHFSV FCASGRQDLL YKYSFSARGN PPRILYQGRD
FQYYFNLPSG DPSDDYKVTI YTEIRSGRYG SATRPCPVTV RVKPSFVRDN SSSSPHPDPD
LKLSESGLQT LSALLQLGNS AEVRNHVSLL CSVLNRLSRG TEAEAQRRLR NALICTVCEL
ESSDQVHSDL QTAPAHSATG FTELFLVTLM SIRRVTSHVQ AVSEQFSEVI TADSNHRLLD
SLISLLSYTL QAVSSCDSSP ETLSGELESE SSTDHNEKGS ENAPDCCLTH STCDHFKHVG
SIPIKQVLQL VGDILQTASD LMLVRRNIQL STKELIVNSG LVTLHAASQN QTSTTIRSNL
TTVDLPESLI HAVFVRLRGR ARLREPNVCV LRVLVKLSRS PYCWASYPAQ LTGPVVDLSL
YKCSTRRRIH VGSLPQPISF ELHHPQTNRS SVSEYSLLRG RINYHNFSIS QELLHQAVQV
TVVFTPPPTK EFPIMLLFRM FERPTPSMHH LQRIHKWESD TVRITLPPSY FNAAGVGHLA
LLDANFGKAS RRKRKSEQIS YGVSVDSSLC LSWDGQQGDW THHSCRTQRL DTSVNCSCFQ
LRPLTVFQQQ IPSSHDTADL DQFLSVSSNL TVFSLLMLVL ILFIPGLMWT QRADVVSEEH
RRVHFLSDNN PEDSYLYAVC IHTGLRSAAC MTAKVFIVLC GELGLSQTKE LQAPGCTLFR
RNAQDTFMLS AAGSLGTVWG VHIWHNNSGP SPDWYIKHVM VSEVSSGQVG RSWLFVGESW
LAVNEDDGQV ERMLHVGGLG FARMLSLRFS DYLADFHTWI SVYSCRWPNS FTHTQRLGVC
LLLLSGYAAV NAVIVAQTDD QLESGIVGVS VVSITAGLLS VVIVLPAATL ISFLFRLCGI
KPTGSGVQHG SFRMTAKQDS EGQDTDMLSV STTLENKDTN EEPVIQAKRR QDSVAFGSSR
GPSQGLSLTS EGSYCEGTEG GFSPERDGFG FQKTTRKEGQ TFQNKRHFGV TSMRCLFLAW
ALCLLISLLC LVLSASLGFR FSSSQVLLWI QSLFVSLISC IFFIQPALVT MRVCSARIEF
LSHSNINLFL ILSCSELVRG PATSASCARR QKERLLSRKH SGSSLCACVN LHVCNRNLMF
FFSSCRDLSV CAAMLLLMTC INYYSSFKEH YQLNRAVKRH FLRNQGFISI KTHKDWWKWT
QTALLDLLDQ NKSDKTEPSY VGIGDLVIKK TETYQTSQNQ VVCKPPLMLS VFLCSSDAAS
ELELLRSSGW VGGQTVALKV QFTLYSPAPN LFTGVTLLSE RSPSGVLRPS VKVQSVRVDA
APAGWDHVVT LCQLLFLLLS LLQLCNQVST ATQKGLMGYW RTPSTWLDVS LNTPPSKKKK
RKSFIQLGHV HTRTHTNPNK ITVASVKGRN NLSVLN
//
