ID A0A3Q3GEL1_KRYMA Unreviewed; 504 AA.
AC A0A3Q3GEL1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=SPARC related modular calcium binding 1 {ECO:0000313|Ensembl:ENSKMAP00000022127.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000022127.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000022127.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_017271054.1; XM_017415565.1.
DR AlphaFoldDB; A0A3Q3GEL1; -.
DR STRING; 37003.ENSKMAP00000022127; -.
DR Ensembl; ENSKMAT00000022412.1; ENSKMAP00000022127.1; ENSKMAG00000016418.1.
DR GeneID; 108235509; -.
DR KEGG; kmr:108235509; -.
DR CTD; 64093; -.
DR GeneTree; ENSGT00390000018436; -.
DR OMA; GERDNHC; -.
DR OrthoDB; 5388426at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0002072; P:optic cup morphogenesis involved in camera-type eye development; IEA:Ensembl.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 2.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR PANTHER; PTHR12352:SF13; SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF16597; Thyroglob_assoc; 1.
DR Pfam; PF00086; Thyroglobulin_1; 2.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 2.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..504
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018605359"
FT DOMAIN 38..90
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 117..183
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 275..343
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 447..482
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 99..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 154..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 163..183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 313..320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 504 AA; 55308 MW; 299B4DF8A0C73F14 CRC64;
MFLSGGFVGT FSWLLAPIFL SHLAEVSAQK SGARWLIGDR DTPCGVVCSR TLGKPVCGSD
GRSYETSCEL QKARCRDKTL TLAHRGRCQV KTFQLPVAPA PTSTPEARHT EFKDAGQSKC
RTERSDALEQ SRRPHESIFI PECNSDGTYA QVQCHTLTGY CWCVNNDGKP VSGSSVRNRT
PVCSGNLREY MGTNAGKSGL PGSVTDKPPG PPTTGKKVSF RFFLTLNPDD GSKPTPTMET
HVPPEEITAP TLWIKHLVYK ENKQNNSTSK KQEKGPSCDQ ERQIALEAAG QSPYNTIFIP
DCGAGGLYKA VQCHQSTGYC WCVLVDTGRP IPGTSARYMT PECDENARSQ ITEIEDPFLD
RPLTGCPEGK KAEFITSLLD ALTTDMVQAI NSPAPSGGGR FVEPDPSHTL EERVVHWYFA
QLDNNGSHDI NKKELKPFKK YLKKKAKPKK CARKFIDYCD LNRDRAISLQ ELKGCLGVSK
EGSSVSSSML GTRQGPNLFI GRLV
//
