ID A0A3Q3GH69_KRYMA Unreviewed; 456 AA.
AC A0A3Q3GH69;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Iroquois homeobox 5 {ECO:0000313|Ensembl:ENSKMAP00000022937.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000022937.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000022937.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC {ECO:0000256|ARBA:ARBA00008446}.
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DR RefSeq; XP_017279124.1; XM_017423635.1.
DR AlphaFoldDB; A0A3Q3GH69; -.
DR STRING; 37003.ENSKMAP00000022937; -.
DR Ensembl; ENSKMAT00000023231.1; ENSKMAP00000022937.1; ENSKMAG00000017013.1.
DR GeneID; 108240273; -.
DR KEGG; kmr:108240273; -.
DR CTD; 573346; -.
DR GeneTree; ENSGT00940000159483; -.
DR OMA; CPFPNSA; -.
DR OrthoDB; 2915644at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0072498; P:embryonic skeletal joint development; IEA:Ensembl.
DR GO; GO:0032330; P:regulation of chondrocyte differentiation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR PANTHER; PTHR11211:SF17; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-5; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 115..172
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 117..173
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 175..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 48908 MW; 6937671343567539 CRC64;
MAYPQGYLYQ PSASLALYSC PAYSTSVISG PRTEELGRSS SGSAFAPYAG STAFTSASPG
YNSHLPYSAD AAAAATFTSY VSSPYDHTTG MAGSIGYHPY AAPLGTYPYG DPAYRKNATR
DATATLKAWL NEHRKNPYPT KGEKIMLAII TKMTLTQVST WFANARRRLK KENKMTWTPR
NRSEDEEEDE NIDLEKNDDD EPNKPLDKGD STDTEADHKL LNPGDMGCDR FKEENRGKEM
DPLLSDSELK DQEERTTELL PDSAKPTTSS PAAGPRGNQA AAQPDKPADL GHAPNAVTSN
VTSVIHSPPS APKPKLWSLA EIATSSDRCK GSGGGGGDAS QACPGLGQSA VLGSTASPSR
SSPQCPLPNS TVLSRPLYYT SPFYPGYTNY GGTFGHLHSN HGSVTTGSTA HFNGLNQTVL
NRAEALVRES QKVRGQTQVD LCKDSPYELK KGMSNI
//
