ID A0A3Q3GJ32_9LABR Unreviewed; 960 AA.
AC A0A3Q3GJ32;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Integrin alpha-V-like {ECO:0000313|Ensembl:ENSLBEP00000031559.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000031559.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000031559.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3Q3GJ32; -.
DR Ensembl; ENSLBET00000032985.1; ENSLBEP00000031559.1; ENSLBEG00000023575.1.
DR GeneTree; ENSGT00940000158361; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 2.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF4; INTEGRIN ALPHA-V; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 3.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 25..960
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5018382743"
FT TRANSMEM 921..942
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 29..93
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 104..165
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 271..336
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 337..395
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 469..602
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 603..703
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 746..843
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 960 AA; 105107 MW; 16E6516EEFED9D5E CRC64;
MAGRGRAAVG LLVLLCSLFG PCGSFNLDED KPFVFSGPEG SYFGFSVDFF QASTDLRSDV
LIGAPRANAS SSSSVVERGA VYSCPWAGSS SCQQVLFDSS DDRTNTEGAK MEFKSKQWFG
ASVRSDGEHI LACAPLYQWS TYGVSEREPV GTCFLKKGDA VVEYSPCRSS QSANSPEGQG
FCQAGFSCLY LISSLNFSNV LFLSSGQLIS DDVAEIFKRF DKKYVIPYGN TLSTKSASAQ
YDDSYLDYVT GVPRGDKALG YVNIFNNLNM ESMVNFTGTQ MAAYFGHSVA ATDVNNDGLV
DLLVGAPLFM DRGPDGKLRE VGQVSVYLGR GGFSFHPPQQ LIGSEVYARY GSAITTLGDL
DMDGFNDVAI SAPYGGPDRY GRIYIHNGRP QGPNATPSQV LKGKWASSYM PSSFGYSMTG
NTDIDKNGYP GTQTHKNTRA RVHTQQGRGV LSVFLSFRFN SRGVWSRQSC FIQVTYSLCV
FKVKYCLKAS GISAPPTLNF RVDLELDRLK QKESTKRVLF LHDQAFHYSK NMVVNNGKGP
TCEEQFVYLG VRHHVRDKIT PISVAMDYTL NYQMAADPTG LLPILHMSTP SNVTKQAHIL
LDCGDDNICK PDLKLSVKSD REQIYIGDDN ALTLEVVAEN KGEGAYEAEL HIYPPQLADF
TRVVPSDTHS RVSCTYKKEN QTKIVVCDLG NPMKAGTVVS KSTRLVLRAG PLLSPCSLIG
PLLSNQFDNT SPRVSSVTKL AVLAKVSIRG TSSPSQILLP IANWKPRHPA VSVDDQGPQI
VHVYELLNSG PSTFSKASLE VELPYHYKND SLLYVVSFET EGPINCTTDI ELNPLNLSVS
GGSTGEGEER HRVHLLQTDL FCLFLRQTEN QNRSYMVQST ASFNVIEMPY KNLDSELSSN
STMVSVSVMW VAEPPQSVPG WVVALAVLAG LLLLALLIFI MYKCSLSQLV INGLLRQDET
//
