ID A0A3Q3GKV4_9LABR Unreviewed; 1058 AA.
AC A0A3Q3GKV4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Integrin subunit alpha 8 {ECO:0000313|Ensembl:ENSLBEP00000032069.1};
GN Name=ITGA8 {ECO:0000313|Ensembl:ENSLBEP00000032069.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000032069.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000032069.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3Q3GKV4; -.
DR Ensembl; ENSLBET00000033511.1; ENSLBEP00000032069.1; ENSLBEG00000024146.1.
DR GeneTree; ENSGT00940000156737; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF5; INTEGRIN ALPHA-8; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1006..1028
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 35..102
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 118..179
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 184..236
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 303..368
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 369..427
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 434..496
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 481..637
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 638..778
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 784..995
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 1039..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 115970 MW; B173A31CAD80B762 CRC64;
MGMERPSHCV SSAGIFILGL LSVLCPALNG VWSFNLHAEH PTVYRGPEGS YFGYSVDFYQ
ATSDSNTFSV LVGAPKANTS QPGLVEAGSV YYCPWPGLPD SCRQIPFDNS NNRMIKVNKT
REPLEFKSHQ WFGASVRSHK GKVVACAPLY HWRTVKLSGE KDPVGTCYVA VQNFSAYAEY
SPCRTNDPDP EGQGFCQAGF SVDFTKEGTL VVGGPGSYYW QGQVMTAGIA EILNGYSLKA
VLRRVPGEKY TRAAEDTHDD SYLGYSVAVG EFTGDSEQEL IAGVPRGAQN FGYVVMINST
NMTFILNFTG EQMASYFGYS VAVTDLNGDG TDDVLVGAPL YMEREMESKP REVGRVYLYL
QTAPLTFSEP VALTGTYTFG RFGTAIAPLG DINQDGYNDV AVGCPFGGEG RGGRVLIFNG
NRDVSIRGLT LSQELRAAGV PGDGLPGFGF TLRGGQDLDN NQYPDLIVGA FGASEVSVYR
SRAVVSVEAS LTLTPRILNP DDRQCHLPET DIMVTCLRVD VCAAVSGVGI PSSLDLRAEL
QLDWLKGTRG GVKRVLFLDT QQPQRIGLLT LSHNLPRACL SYTIFLREEE EFRDKLTPIS
LALNYSLAPP TRGQSLPPVL NQYSSTFLQE HAYILLDCGD DNICIPDLQL SATMDQSELV
IGDDNLVMLT ITALNQGEGA YETELHTLIP PEADYIGVER RVESLSQLNC EYKMVNDSRL
VVCDLGNPMV TGTELSVGLR FSVQRLDDAG PKISFELQIH SSNKDNSHSN PVTLNLSIIA
EAHLDLRGVS HPSQVVLPFP NWEPKEKPVK EDDVGPQVTH IYELHNFGHS SIQDAELQVG
WPSRFRDENL LYAMEIQTDG PISCRTNTSL NPLGLQISSL QDTPELLGFL RNTSAPPTRR
HKRAVTAAQS YSDKTLNCTN ISCLKIMCVV GRLDRGQSAV VKIRSRLWAQ TFLQRRNDPY
ILNSTVSFLV TALPYRVQPS SLPHHSTSMG TLVLWGTPDV SFAVPLWVII LAILLGLLVL
AMLTLAMWKC GFFDRARPPA DDDVSDQEQL TSDQTGDA
//