ID A0A3Q3GL37_KRYMA Unreviewed; 323 AA.
AC A0A3Q3GL37;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Cytochrome c oxidase assembly protein COX18, mitochondrial {ECO:0000313|Ensembl:ENSKMAP00000024272.1};
GN Name=COX18 {ECO:0000313|Ensembl:ENSKMAP00000024272.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000024272.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000024272.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003945}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003945}.
CC Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family.
CC {ECO:0000256|RuleBase:RU003945}.
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DR RefSeq; XP_017293521.1; XM_017438032.1.
DR AlphaFoldDB; A0A3Q3GL37; -.
DR Ensembl; ENSKMAT00000024578.1; ENSKMAP00000024272.1; ENSKMAG00000017988.1.
DR GeneID; 108248953; -.
DR GeneTree; ENSGT00530000063506; -.
DR OMA; IIVLWGQ; -.
DR OrthoDB; 5395681at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR CDD; cd20069; 5TM_Oxa1-like; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR PANTHER; PTHR12428:SF34; CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003945};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 81..291
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
SQ SEQUENCE 323 AA; 35545 MW; AA625C7D38463E34 CRC64;
MLSAGGLVRS RVLRLRGPAA GLVRWAGPAT VSVPEPRVRS VSGVGGASGA GGWYGSLSDS
APVHLCEHFL VGVQQVSGLP WWLSIAMATV SVRTLITLPL ATYQLLILSK VEALQAEISE
LAKRLRYEVS VRARERGWTE KQSRVQFQKN LRRLVSQLYI RDNCHPFKAS LVVWVQLPLW
VSLSLALRNL SLDQSALRGE LAAGGALWFP DLTVPDSTWI LPVCLGLTNL VIVEVFSLQR
VGASGFQRLV LNGIRGFSVL MIPIAATVPS SMALYWFCSS LVGFGQNLLL RSPTLHRILR
LPTRRSDSPY RDLLSAFIAK YYK
//
