ID A0A3Q3GQN3_9LABR Unreviewed; 700 AA.
AC A0A3Q3GQN3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rap guanine nucleotide exchange factor 5-like {ECO:0000313|Ensembl:ENSLBEP00000032788.1};
GN Name=RAPGEF5 {ECO:0000313|Ensembl:ENSLBEP00000032788.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000032788.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000032788.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q3GQN3; -.
DR STRING; 56723.ENSLBEP00000032788; -.
DR Ensembl; ENSLBET00000034248.1; ENSLBEP00000032788.1; ENSLBEG00000024693.1.
DR GeneTree; ENSGT00940000155137; -.
DR InParanoid; A0A3Q3GQN3; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF26; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660}.
FT DOMAIN 25..82
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 214..340
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 471..699
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 700 AA; 80802 MW; B405B4CE65B7F92A CRC64;
FPCAGRTVRN AFLSNGPVCL YFNRRSYVGV ELVQWLCEQC VYVRCRTTAV RVWQVLLELG
VLLSVDQRVT FSDSNSYYQF SFEECDSASC EFRSNEGEWP EAVRLLLQLI LLKANKGLKS
PCDYILFSFL VKCKCTANMS TDWVVCDQSA EQSVLPNEAE RNTSHLKEFV LASLRNMLLL
FLPKEAVGRV CLKERGRDVL VLRRVTSSVT SPSDRYVVVS GTPLKILEHL LSDLRLDDHR
GGPESRESEM LLDDFLLTYL VFIHKHLTYT LGQEEGKDAL FRKRKVLQLV SHWSRLYKDF
LKDEEHVRSF MKTLYRYVLE DLYEFPTLEK DLKEFQKLLR RRHKQTYQQL SLKENCLQLR
SPPTETREVI CCVYVSADSY LSVQTHHSLE AHELLRIVGL KMDRAEEDMV LAVVSQSGER
RVLQPSDCVY SESLTPQGKL MACRRDLTEI LPPLTDSAEL SRRTVRLLGI NTWDVAAALT
HLDWSLFKSI HEQELVYYTL SRSPGGGHTA ALTVLLQRCN EVQQWVMSEV LMCVSLNKRV
QLLKKFIKIA AHCKAQRNLN SAFAIIMGLN TAAVSRLNQT WEKCPGKFKK LFSELELITD
PSLNHKAYRE AFKRMKPPKI PFMPLLLKDI TFIHEGNKTF HDNLVNFEKL HMIADTVRMI
RHCQSDQPGD VEVRASVHYL HIIDNQQTLF ELSHKLEPRA
//
