ID A0A3Q3GTD2_9LABR Unreviewed; 2519 AA.
AC A0A3Q3GTD2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Desmoplakin b {ECO:0000313|Ensembl:ENSLBEP00000033658.1};
GN Name=DSP {ECO:0000313|Ensembl:ENSLBEP00000033658.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000033658.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000033658.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 56723.ENSLBEP00000033658; -.
DR Ensembl; ENSLBET00000035129.1; ENSLBEP00000033658.1; ENSLBEG00000025091.1.
DR GeneTree; ENSGT00940000154843; -.
DR InParanoid; A0A3Q3GTD2; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002934; P:desmosome organization; IEA:Ensembl.
DR GO; GO:0061436; P:establishment of skin barrier; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 3.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169:SF26; DESMOPLAKIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF00681; Plectin; 7.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR SMART; SM00250; PLEC; 16.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF75399; Plakin repeat; 4.
DR SUPFAM; SSF46966; Spectrin repeat; 3.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 302..367
FT /note="Desmoplakin SH3"
FT /evidence="ECO:0000259|Pfam:PF17902"
FT DOMAIN 402..479
FT /note="Desmoplakin spectrin-like"
FT /evidence="ECO:0000259|Pfam:PF18373"
FT REGION 15..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2225..2245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2459..2519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 166..193
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 265..295
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 847..1025
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1052..1146
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1185..1454
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1490..1608
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2519 AA; 288255 MW; DAA2C286FD0BF07B CRC64;
EICNDQLNGV HMAMSGTLTR RRSTRGSSGG WEEPPRSFQD AMGWIAQQKR LIETASWGDD
AETINQQLNS HQRFHSSIQR STEMERARDE LVKKGDKASL HALEQEWDSL QKMSFGRTEQ
LQELQNIIQE MSKEIMWVNE KEEEELMFDW GDKNIDQYIP KKQESYSKLM SSLEDKEKDL
NKLKAKVDTL LKNNHPAADK IEAYKDTLQT QWSWLLQITK CIDTHLKENS AYSQFFREAN
ETYSSLQKEH ETVRKMFTCD KNTSLEDLLD LLRGLEREKE KIMENKRQVQ HLVNQSKNIV
RLKPRNPEDK SSSQIIVKSL CDFKQDQKVI CKHDEAILKD NSQRSKWNVT GPGGLDMTVP
SVCLLVPPPN PISISLANKN EQYYDAIMSI WNQLYINIKS LVAWQYCLLD LKRINSLTIS
MLAKMRPEEY RQLIKSLEIH FEEFKLSSVG SQMFGDEDKR TIESQFNGAQ NHYEQLVVQL
PTYSQFVKGV KADPGKKKGV CCSRSLSELH ALRLRLDGAE DTLSQHVHIL CVCVCVCVVL
QMVQRDVDSM REEFLRLRER IVKELEGMTD ADKAQFLCSE IGIIDQRLAS LDSKTHFSNA
EDIVKVYEAR LTEKETTSLT PIEVEEYMSA LMKMKSDLDQ KKDILASMEA ELAKASHWNG
QVGAPFHRCD IMLSKYNEQV SQLSDRWRRI VGQIDTRVQD LQSYEPQLQR YKQTSSSLSD
WIDTTKRRQD SLQATKINSI EVLKEHINTQ KALNSDIKSK RGTVDIVLRD NEACVTSIKD
YESDLNSYTS GLETLLNIPI KRTMLKSPSM DLNQEATQLQ TRYMELFTQS ADYYRYLGEL
LKNMEELKMR NTRIDLLEEE LRLLREDMHD RNSKNKSLED ALARAQLELN MSKDQLQSME
EVKVTTARQV NATRESLDST QSQLADLNDQ VTRLKYLLEE EKRKKRLAEE RYTHQQEEYE
LVLSRRQKEL ETVSWSKVDL EKSVANKEQE IEQLRRQLAD EASRVKELQK EISKVRSQCS
MEINNLKLNF ESQIQVSRTD VQRLAAQKDE DTTELRLQYD RTVAERNDLE EELRRLRLSL
NQAEEKRKWA EEETQSQRAV ITEEGRRRRE LESKVDGLMR QRDEQSSQYE EELADVLKRL
QDKSEELVYI THSLEEETRR RKTIEEGQDV LEQTLSQLQS KLSSSSMTTA QLRECKDELE
KLRLELERES KERSRVEQNM SRLQGRMKDL QAMRDGLESQ VENLRVANQE EIARRKQIET
ELDKTTTTMT EYNRTINTLR QSQENASMSG KRVEEERLRL QGELEESLRQ NKTSEEQTKR
LSTELKALQQ QLLQEQARVK EANFKNESLY KTIEERNMAL NESTSEVQRL KDMTESQTRE
RLRLEEELRT TRQEKVELLK TKQGHNDELS SQITALQLQL QASEHSNVDY RNLVSELSSE
REKLMLEAEK IQKQATEVHG SLTLKHGSIQ SKYNDIVIER DDLLRRLRLS DNDRSSLQRL
EDELNRLKLS LESELRNKQR LQDENDRLKR DVSNWKVQFE SKQEVIKQYE TDKNRLEREK
NSLNSEIERL MRQLRELEEM YKSKLSAIQK ELNDMAVLRQ NMEAELRKSR ETPALDASGV
IFDGVRKKVT ADQLLDCGVL DNLTFSQLAK GHKTVPEVSA DKKINLKGTG PIAGVIVEGQ
KGSGSANGLL FKMTFAEAKK ENLLPPDSID LLLDAQAATG HIIDPTTNEK LKVEEACAIG
LVDNKDRGRL LAAEAAAVGF KDPRTGKPLS VFEAMTKGLI DQKTGLRLLQ AQESAGGILD
PTLSVFLPRD MAIKRNILDE DLCRALNKKP ECYLDPDTQQ GTTYIALKKT CKVDPSTGLL
LLPEPKKPVT VQGLRDQVSV MDLVDANLLK RSDMDKLREG RLTSRDIEDR LGSYLRGSTC
IAGIYDEANE KVLTIYQAMK DGLLKPGTTL ELLEAQAASG FIVDPVNNHF LSVSDAYSKR
LFGPEYKDSL LSAERAVTGY QVPGTDKVIS LFQAIERGLV EKGHGIRLLE AQIASGGIID
PEHSHRIDVD VAYEKGYFDE RMNRVLSSPN AETKGFFDPN TEENLTYKEL KKACIRDKKT
GLILLPIIDK SKLESTTRKR RVIIVDPETN KEMTVREAFD KGLIDYDTFI DLSEQECEWE
EITITAPDGS TQFKLVDNKT GREYDITELL EKRVISQSDL DQYKSRIITL TQFADIITKK
TRGLSRPSAE TTTLTERSSK SSIISRDMPD CGKSLSSVSV TLSSPVVTIG EQEPVGAVFD
TENFEKISIF EALNRGLVDT ITAQRLLEAQ ACTGGIINPK NGNRLGIQEA SRLGIIDENM
ASKLKPAQKA YVGFEDVKTR KKMSAAEAIK EKWLPYEAGH RFLEFQYITG GFHDPETGCK
RTIQDALQMG WLDERTAQKL QDVKKQTKNL TCPKSKLKIS YTDALDSCMS EERTGVRMLP
ASSVSSSGIS SPYNVSSAPG SNTGSRSGSQ RGSRRGSLDL GSPAATTSRY TFSSFTSSK
//
