ID A0A3Q3GUZ4_9LABR Unreviewed; 2028 AA.
AC A0A3Q3GUZ4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rho GTPase activating protein 32 {ECO:0000313|Ensembl:ENSLBEP00000038302.1};
GN Name=ARHGAP32 {ECO:0000313|Ensembl:ENSLBEP00000038302.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000038302.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000038302.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC {ECO:0000256|ARBA:ARBA00008795}.
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DR Ensembl; ENSLBET00000039875.1; ENSLBEP00000038302.1; ENSLBEG00000028551.1.
DR GeneTree; ENSGT00940000154313; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF13; RHO GTPASE-ACTIVATING PROTEIN 32; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 252..314
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 390..585
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 718..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1524..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1607..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1824..2028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1305
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1829..1856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1895..1953
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1990..2010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2028 AA; 223528 MW; 1B771FBA1EE9B218 CRC64;
MEAGSGAAAA VGSTALGLLG ATATSSHDIL DRGLRSGRHL EDDDIVPELA YIHPRERPDW
EETISAMARS AEIPELRAEP LMRSCSSSTA SMKVKNVKKL CFTKGHFPKL AECAHFHYEN
VDFGTIQLSL GDEQCEVTRN GFESKELVYL VHIYCQGRSW IVKRSYEDFR VLDKHLHLCI
YDRRFSQLPE LPRLDSLTDQ SESVSQMLLA YLSRLSAIAD NKINCGPALT WMEVDNKGNH
LLVHEESSIN VPAIAAAHVI KRYIAQASDE LSFEVGDIVS VIDMPPKEDT TWWRGKHGFQ
VGFFPSECVE LINDKVPQSM TNTVPKPDLE MESVIQDNAW VADPLNHYSI SSVSKKHGKL
ITFLRTFMKS RPTKQKLKQR GILRERVFGC DLGEHLLNSA HDVPQVLKSC TEFIEKHGVV
DGIYRLSGIA SNIQKLRHEF DSEQIPDLTK DVYIQDIHCV GSLCKLYFRE LPNPLLTYQL
YEKFSEAVSA ATDEERLIKI HDVIQQLPPP HYRTLEFLMR HLSHLAAFSY ITNMHSKNLA
IVWAPNLLRS KQIESACFSG TAAFMEVRIQ SVVVEFILNH VDVLFSSKLS SLIREGAGHN
SLSRPKSLLV SSPSTKLLSL EEAQARTQAQ INSPVTEDSK YIEVGEGPAA LQGKFHTVIE
FPTERKRPPI KSKKSPVGSW RSFFNLGKSS SMSKRKLTRN PSEPNELKAM ALAGGRGDTA
TLRSAKSEES LSSLHNVEGE SKVYRPRRPR SSSDALSASF NGDLLDSRQH CNSYDNLDGT
EDSDGDDGPI CVPALISPPR SAGEDVDLSP PDIGMASLDF DPMSFQCSLP DTSYAFPLDD
SPAGAEGSTL KRSPGSKSNG SDLMSASFLG SLTSPLLSGD FCYREKIESK KLTTSYSYTD
KPTQAVSPIK CAKTTSLTPL ATSELFSVEK PDDRNTAAHP VSSQPLSPPA AAKDSPPLMG
SVLLRAAEPS LSEAFQMELH SKLATFDSVD SQELKGDDSV QQEPAASSQE QQGVVAPDSS
KDLTPRFLSS TAPSAAPPPP PPKNAARMLA LALAESAQQV SVQSQFRSSE PPTPVSPLQT
HEESDLLGVA HPKVQHFQTS SEDGAERESS LPPNSTAPTV TTTSSYPSAS SPAIKLQPLE
LTSTITKLPD SAKSSTTPLG PHPDTDSSST DTTLYKCVPL PSSTSLSSPT RKSPERQQSV
PAHVPVHIPV HVPVHVPVHV PVHVPVHVPV HVPVHVPVHV PVHVPVHVPV HVPVHTNSSS
NTPATTPSGS RKDTRVLPQP VPEVKPGETS PRPILPKPSD QPPPIKPKRQ ALSQHQTQTQ
QQSQAQIQAH LQTQSNSQPH PPSQPNTQPQ TPALPQTHTQ PPSKASARVA PTSAEPVEKP
WEAIKPVQPC TEPVKYHEVY GPPAPPVRTI ESKLATAALS QSEASYHVLA EGPTPGHLEE
ALPHHPPSPR KSSTHQPAYL YHAKAEPVLM EPPGAAYYHQ RPVPLGPQTM PHHYRPDSVP
PHLSFVSKSE PQIPYSARVD NRYSTLGPRS YHHSIKSRGN SRGVYVSPGP GHQGYSHDRT
HGYPTIRRVH SLHVPSTIRT VPIQRTEVPP DDEIFFYHRP VYPCKAYQQP PQQQQPPQQQ
QQQQQSSQGD YHVTQLQPYF ENGRVQYRYS PYSGSGPVEA PYYDIDPYGT IRVRHFHSRD
PGAAAGRPGG KATGYHYLAR HVLPPGKEHS FVSRDMPPGH ASMEAPAYLS WDPEESERLR
FQSIRRESRA RQKVKGPVLS QYDNVGLFAP ADISGYEMLH LRSKSDPGKA VLAAAESKDG
RYLPRHMTSD PDVVLYMETD KHVQGDRSEG LAKQSTSKKC QSSHSFPSSL SHSLSHQQES
SRHDAKPADD KQGTDGSRSK HWQQEYPSKR SFTPRYECPD SDHKGKSGYH STEEQPSDPR
DQHAHSKPER SHSVREPPHY SKPEPDRDYS YQKHSSKAAQ SHYDNLDDYR PVPQPQAPLH
KRGGSGSYPG PGFSVSQNNR AYSTALGQGG YIQTDLALPR PETEIRTE
//
