ID A0A3Q3GWM9_9LABR Unreviewed; 565 AA.
AC A0A3Q3GWM9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000035729.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000035729.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A3Q3GWM9; -.
DR STRING; 56723.ENSLBEP00000035729; -.
DR Ensembl; ENSLBET00000037241.1; ENSLBEP00000035729.1; ENSLBEG00000026792.1.
DR GeneTree; ENSGT00940000163785; -.
DR InParanoid; A0A3Q3GWM9; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF10; SOLUBLE GUANYLATE CYCLASE 88E; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660}.
FT DOMAIN 490..519
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 290..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 426..453
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 290..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 66173 MW; ACE952A95C5313D5 CRC64;
MYGLYLEAVN DYINESYGED VWRLIENRAE IPHLKFVRHQ MYNDNLILRL AKAAGEVLGK
THDELMYAFG VYMVKRIGNY GYERILKVLG RNVRDFINEL DNLHEYFRFS FPKVQPPSFC
VEEECETSLT LHYRSTRKGF TQFVKGQLSQ VGRQFYNTDI EVEILSKEET EKMTYVVYKM
NFDNAAFKHR MPQQKTAPGY EKLPMKRGIF FDMFPFSVIF RRDMTMYRIG DGLKEVFSDL
QGKKVNEEFT LIRPMLEFSW DNIYFHLNNV FELLSRAVVE SKQKVNIKLS KEEPDEKEES
EKVKREEERE QNDVEEMKGT DQEYNSALTQ YNSSANSGGE DIELLAFQTV TGKCSETIFE
DMREPPKKPL HLKGQMKYVP QWDSLIFLGT PIIETVEDMI KMGVYVNDLN LHDSSRELIL
AGTQQSAELQ LALDQEQQKY AQLMEIIKKL DEEKKRGDSL LYAMIPKAVA DRLRKGITAL
ETCQVFPDVT ILFSDVVKFN EICIHITPMQ VVDMLNEIYI VLTHSVRSTT STRWRRSAMP
TWWWPASPTK PRFTPTISVT WRWTC
//
