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Database: UniProt
Entry: A0A3Q3GWQ0_9LABR
LinkDB: A0A3Q3GWQ0_9LABR
Original site: A0A3Q3GWQ0_9LABR 
ID   A0A3Q3GWQ0_9LABR        Unreviewed;       690 AA.
AC   A0A3Q3GWQ0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Leucine zipper putative tumor suppressor 2 homolog {ECO:0000256|HAMAP-Rule:MF_03026};
DE   AltName: Full=Protein LAPSER1 {ECO:0000256|HAMAP-Rule:MF_03026};
GN   Name=LZTS2 {ECO:0000256|HAMAP-Rule:MF_03026,
GN   ECO:0000313|Ensembl:ENSLBEP00000037746.1};
GN   Synonyms=LAPSER1 {ECO:0000256|HAMAP-Rule:MF_03026};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000037746.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000037746.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Negative regulator of katanin-mediated microtubule severing
CC       and release from the centrosome. Required for central spindle formation
CC       and the completion of cytokinesis. Negative regulator of the Wnt
CC       signaling pathway. Represses beta-catenin-mediated transcriptional
CC       activation by promoting the nuclear exclusion of beta-catenin.
CC       {ECO:0000256|HAMAP-Rule:MF_03026}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03026}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000256|HAMAP-Rule:MF_03026}.
CC   -!- SIMILARITY: Belongs to the LZTS2 family. {ECO:0000256|HAMAP-
CC       Rule:MF_03026}.
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DR   STRING; 56723.ENSLBEP00000037746; -.
DR   Ensembl; ENSLBET00000039308.1; ENSLBEP00000037746.1; ENSLBEG00000028175.1.
DR   Ensembl; ENSLBET00000039310.1; ENSLBEP00000037748.1; ENSLBEG00000028175.1.
DR   GeneTree; ENSGT00940000154078; -.
DR   OrthoDB; 5394101at2759; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-UniRule.
DR   GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR   GO; GO:0000281; P:mitotic cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0051168; P:nuclear export; IEA:UniProtKB-UniRule.
DR   GO; GO:0051255; P:spindle midzone assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   HAMAP; MF_03026; LZTS2; 1.
DR   InterPro; IPR045329; LZTS.
DR   InterPro; IPR028597; LZTS2.
DR   PANTHER; PTHR19354; ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR19354:SF4; ZIPPER PUTATIVE TUMOR SUPPRESSOR 2-RELATED; 1.
DR   Pfam; PF06818; Fez1; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW   Rule:MF_03026};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW   Rule:MF_03026}; Coiled coil {ECO:0000256|HAMAP-Rule:MF_03026};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03026};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212, ECO:0000256|HAMAP-
KW   Rule:MF_03026};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|HAMAP-
KW   Rule:MF_03026};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|HAMAP-Rule:MF_03026};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|HAMAP-
KW   Rule:MF_03026}.
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          666..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          524..558
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03026"
FT   COMPBIAS        289..328
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   690 AA;  76762 MW;  2FDF09ABCEE9032D CRC64;
     MALVQALPIS TEPHTPGHSG SRRRHHSSSS PVNAPPSALD PMGSVSSLIA ARPGPYQDLR
     SGGELGARVR RPTQGASCLG SESPQDPLLQ NILPLLKQSS TGSGRGLMEK ESGNGNHTYL
     NEDFIGDWND NHVTPVSPGT DVDGSQEVSG LNGNMGGPPP KLVPVSGKLE RNMEKTVLRP
     TAFKPVIPKN RTSMQYLSPR HVANVSESQN NLNLLSPTHR ESSPSSTEKS NAYGRTRNGG
     SGCNQPCQLT DSGRNSLCSI PPYSSAPYSQ TSGETTAGHL EPMKSAPPVS THGHSNSDSG
     RSSSSKSTGS GSISGRGHPL SDSGSSGRSP GPVEGYEGVV RDLEDKLRER ELELQTLRDN
     LDENEAAICQ VYEEKQKRFE LELEELRQGC ATRMQVASQK AQRAQQVLQL QVYQLQQEKK
     KLQEDFAQLL QEREQLEERC TSYEHEKIQL GPRLEESKWE VCQKSGEISL LKQQLKEVQG
     ELSQRVGEIV SLRGQLRESR GELTNTQVLL QEANGTTRTR TLELEVCENE LQRRKSEAEL
     LREKVGRLEG ELVHLRDALA NQGPGNRQCQ VFHEAEEHML AYESDEAKAQ RQSTSEALQS
     MKLQMDRMKS ELAFEHQRAE QQMGGFEEER KIWQEEKDKV IRYQKQLQQN YVQMYRRNRE
     LEQLLQELSQ EEDEGSGNEI NFDEIAATEI
//
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