ID A0A3Q3GWQ0_9LABR Unreviewed; 690 AA.
AC A0A3Q3GWQ0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Leucine zipper putative tumor suppressor 2 homolog {ECO:0000256|HAMAP-Rule:MF_03026};
DE AltName: Full=Protein LAPSER1 {ECO:0000256|HAMAP-Rule:MF_03026};
GN Name=LZTS2 {ECO:0000256|HAMAP-Rule:MF_03026,
GN ECO:0000313|Ensembl:ENSLBEP00000037746.1};
GN Synonyms=LAPSER1 {ECO:0000256|HAMAP-Rule:MF_03026};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000037746.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000037746.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of katanin-mediated microtubule severing
CC and release from the centrosome. Required for central spindle formation
CC and the completion of cytokinesis. Negative regulator of the Wnt
CC signaling pathway. Represses beta-catenin-mediated transcriptional
CC activation by promoting the nuclear exclusion of beta-catenin.
CC {ECO:0000256|HAMAP-Rule:MF_03026}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03026}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000256|HAMAP-Rule:MF_03026}.
CC -!- SIMILARITY: Belongs to the LZTS2 family. {ECO:0000256|HAMAP-
CC Rule:MF_03026}.
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DR STRING; 56723.ENSLBEP00000037746; -.
DR Ensembl; ENSLBET00000039308.1; ENSLBEP00000037746.1; ENSLBEG00000028175.1.
DR Ensembl; ENSLBET00000039310.1; ENSLBEP00000037748.1; ENSLBEG00000028175.1.
DR GeneTree; ENSGT00940000154078; -.
DR OrthoDB; 5394101at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-UniRule.
DR GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:UniProtKB-UniRule.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0051168; P:nuclear export; IEA:UniProtKB-UniRule.
DR GO; GO:0051255; P:spindle midzone assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR HAMAP; MF_03026; LZTS2; 1.
DR InterPro; IPR045329; LZTS.
DR InterPro; IPR028597; LZTS2.
DR PANTHER; PTHR19354; ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR19354:SF4; ZIPPER PUTATIVE TUMOR SUPPRESSOR 2-RELATED; 1.
DR Pfam; PF06818; Fez1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW Rule:MF_03026};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW Rule:MF_03026}; Coiled coil {ECO:0000256|HAMAP-Rule:MF_03026};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03026};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212, ECO:0000256|HAMAP-
KW Rule:MF_03026};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|HAMAP-
KW Rule:MF_03026};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|HAMAP-Rule:MF_03026};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|HAMAP-
KW Rule:MF_03026}.
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 524..558
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03026"
FT COMPBIAS 289..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 76762 MW; 2FDF09ABCEE9032D CRC64;
MALVQALPIS TEPHTPGHSG SRRRHHSSSS PVNAPPSALD PMGSVSSLIA ARPGPYQDLR
SGGELGARVR RPTQGASCLG SESPQDPLLQ NILPLLKQSS TGSGRGLMEK ESGNGNHTYL
NEDFIGDWND NHVTPVSPGT DVDGSQEVSG LNGNMGGPPP KLVPVSGKLE RNMEKTVLRP
TAFKPVIPKN RTSMQYLSPR HVANVSESQN NLNLLSPTHR ESSPSSTEKS NAYGRTRNGG
SGCNQPCQLT DSGRNSLCSI PPYSSAPYSQ TSGETTAGHL EPMKSAPPVS THGHSNSDSG
RSSSSKSTGS GSISGRGHPL SDSGSSGRSP GPVEGYEGVV RDLEDKLRER ELELQTLRDN
LDENEAAICQ VYEEKQKRFE LELEELRQGC ATRMQVASQK AQRAQQVLQL QVYQLQQEKK
KLQEDFAQLL QEREQLEERC TSYEHEKIQL GPRLEESKWE VCQKSGEISL LKQQLKEVQG
ELSQRVGEIV SLRGQLRESR GELTNTQVLL QEANGTTRTR TLELEVCENE LQRRKSEAEL
LREKVGRLEG ELVHLRDALA NQGPGNRQCQ VFHEAEEHML AYESDEAKAQ RQSTSEALQS
MKLQMDRMKS ELAFEHQRAE QQMGGFEEER KIWQEEKDKV IRYQKQLQQN YVQMYRRNRE
LEQLLQELSQ EEDEGSGNEI NFDEIAATEI
//