ID   A0A3Q3H0H8_KRYMA        Unreviewed;       774 AA.
AC   A0A3Q3H0H8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO9 {ECO:0000313|Ensembl:ENSKMAP00000028882.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000028882.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000028882.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   RefSeq; XP_017260992.1; XM_017405503.1.
DR   AlphaFoldDB; A0A3Q3H0H8; -.
DR   Ensembl; ENSKMAT00000029245.1; ENSKMAP00000028882.1; ENSKMAG00000021409.1.
DR   GeneID; 108229825; -.
DR   KEGG; kmr:108229825; -.
DR   GeneTree; ENSGT00940000158300; -.
DR   OMA; KTWARWR; -.
DR   OrthoDB; 534027at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF37; ANOCTAMIN-9; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        191..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        267..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        331..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        377..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        426..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        563..590
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        614..638
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        714..739
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          180..753
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   774 AA;  90211 MW;  FADC4B86839AB83D CRC64;
     MQRHRRQPSI ELLEFLGLVK ENGAEQTPPP VTTPLSYDYI LVAKYVNDYE RQHSRKQAEY
     IDQLKKKNFR VTKIIYDDIV FYGLQAPKEV FERYRYLLKV SDTCNWSTHQ NIMSLSTRIR
     VVHFILNNTE ISSGEVLRDL MKAKIFETKF CLHEKKTQKD LKKKWARWTA CFQGQPVTDV
     RNYFGEKVAL YFLWLGWYTY LLILPAVIGV LVFLYGLSYF NTSPLIKEVC ESDRIMCPLC
     DQSCKVWQLN ETCTYAKLSL LFDNNGTMIF AMFMAIWTTL FLEFWKRHRS AYVFEWKVAD
     WSEEEEELIL EIVNDADCSP KPFKHSYLRS TVVLICVTLM ILVIIGLTHA LVVFRVMVAR
     FLADHEEWEF LNSNSNIGAM MAGAIIHFII ITVMTRVNRI VAMKLCAIEK TRSFAATERS
     FTVKMFTFQF FTYFSSLFYV AFILGRINGH PGDYVRIAGK WRLEECHPSG CLTDLFIQMT
     IIMTLKQTLN NVFEYTGPWF NNYVKKKRSK KLQRKCAVCY QRNESETNAG FEMCENCKLR
     DWQKNYELTD VNSFSLFNEF LEMAIQFSFT TIFVAAFPLA PLLALINNVF EVRLDAIKMV
     TLERRMVPKK TNDIGVWIHI LEVIGVIAVI ANGLVIGVSS DFIPRLVYLY RYGPCVGNTT
     ENMDCMVGYI NNTLSITDTK MFAPKQLVTS GGLNITSCSY KDYRDSDYNF TPQFWLILAI
     RFAFVILFEH VVIICKFIAS WFIPPVPMIV KNDKLIDKLN RLKLELRSFE EGQH
//