ID A0A3Q3H1N1_9LABR Unreviewed; 1204 AA.
AC A0A3Q3H1N1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPN21 {ECO:0000313|Ensembl:ENSLBEP00000037944.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000037944.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000037944.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
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DR AlphaFoldDB; A0A3Q3H1N1; -.
DR Ensembl; ENSLBET00000039508.1; ENSLBEP00000037944.1; ENSLBEG00000028296.1.
DR GeneTree; ENSGT00940000155613; -.
DR OrthoDB; 3108587at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR CDD; cd17192; FERM_F1_PTPN21; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF3; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660}.
FT DOMAIN 23..308
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 927..1197
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1108..1188
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 397..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1138
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1204 AA; 137118 MW; 01F2E83FD6E3B46E CRC64;
MPLPFGFKLK RTRRYTVSSK SCLVTRIQLL NGEFVEFTLS VESTGQECLE AVAQRLELRE
ITFFSLWYFN KQNQQRWIDL EKPLKKQLDK YGLEPTVYFG VVFYIPSVNQ LQQEITRYQY
YLQLKKDVLE GRISCSLEQA VRLASLAVQA DFGDFNRYDS QEFLQKFVLF PIDWIQDERV
LEEATQKVAL LYQSFRGLSA PEAEMLYMQE VEKMEGYGQE SYQAKDSTGT DVTLGSCLEG
IFVKHKNGRP LLLFRWNEIN NMSHNRSFFA LELTNREESV QFQTEDMETS KYVCRMCLAR
LKFYKINKSS LQSQATVVNP VRRRSSTRLS LPKPQGYMMP PPQMHYNGHF TEPYTSSQDN
LYMNNQNGYY YHSQTSLDCP PLEYSSGGRL RNGSVYSAHS TSSLTNPQHY LQPSPMSSNP
SITSDITRPD YIPSHRHSAL IPPSYRATPD YETVMRQKTR GPGGGMVLSQ EHRQSHSMRN
LNIGNSYAYS RPDPLVYSQP EIRGEHGGAA QHLHYPFHLG SSFHSPSPYP YPTERRPVVG
AVSVPELTNV QLQQAQEYPA PNIMRTQVYR PPPPYPYAHP RPANSTPDLS RHLYVSSSNP
DLIITRRVHH SVQTFQEDSL PVAHSLQEVS EPLFSGPPQR HPYHAQKRNS IEIAGLAQSL
EGMRVKERTL SSSAAESATP PPVLHSRQSQ GSQLDVFLER TKKEDRGGNK EGVQYGHKKS
LSDATMLVHS SGEEEEFEED SGRHTPLSQD AAVTLPEQPT QPHHSLTSLS SLKNQQQTPI
EPPPAYPIGS SLDPAVTSSL AYKVHPLIQE NEPLYLLSDL RQPRIMPSVS EGDLSGQAKQ
KTKKDFKKRP VSDVPAGKKT VEGLPPPGMR KGARSEVKKM GPLKVAHLNG LSVSRQPMHD
EIKDEPERAS NDERCKALEQ HMERGELLKE YESIPKRRPS GECNIALQPE SGDKNRFQDV
MPYDDTRVEL VPTKENNTGY INASHVRITV SGQEWSYIAT QGPMSNTCQD FWQMVWEQGV
SIIAMVTAEE ESGREKSFRY WPRLGSRHNT VTYGRFKITT RFRTESGCYA TTGLKIKHLL
TGQERTVWHL QYTDWPDHGC PEDFKGFLTY LEEIQSVRRH TNSISDPKNT NLPVLVHCSA
GVGRTGVVIL SEIMIACLEH NEALDVPKFL SRLRAQRMMM VQTLSQYTFI YKVIIEYLRN
SRLI
//
