ID A0A3Q3H326_9LABR Unreviewed; 1571 AA.
AC A0A3Q3H326;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Adhesion G protein-coupled receptor L3 {ECO:0000313|Ensembl:ENSLBEP00000038624.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000038624.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000038624.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSLBET00000040222.1; ENSLBEP00000038624.1; ENSLBEG00000028794.1.
DR GeneTree; ENSGT00940000155527; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd22846; Gal_Rha_Lectin_LPHN3; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF60; ADHESION G PROTEIN-COUPLED RECEPTOR L3; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 2.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 981..1003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1024..1044
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1064..1087
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1108..1131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1137..1160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..159
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 169..428
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 554..611
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 920..1161
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1456..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..554
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1352..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1412..1436
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 170..352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1571 AA; 173319 MW; 8A3CF4CB94F0B8A3 CRC64;
MVSGALSCDR NSSPQERLSS AGRTSISTSR STSDVMWIRC LLFVSTLFAP IALVSGRAPI
PMAVVRRELS CESYPIELRC PGTDVIMIES ANYGRTDDKI CDSDPAQMEN TRCYLPDAYK
IMSLRCNNRT QCAVVAGPDV FPDPCPGTYK YLEVQYECVP YKVEQKVFLC PGILRGVYQS
EHLFESDHQS GAWCKDPLQA SDKIYYMPWT PYRTDTLTEY SSKEDFIAGR PTTTYKLPHR
VDGTGFVVYD GALFFNKERT RNIVKFDLRT RIKSGEAIIA NANYHDTSPY RWGGKSDIDL
AVDENGLWVI YATEQNNGRI VVSQLNPYTL RIEGSSDTSY DKRSASNAFM ICGVLYVVKT
VYEDDDNEGT GNKIDYMYNT DKGKEMTVNI PFPNSYQYIA AVDYNPRDNL LYVWNNYHVV
KYSLDFGNND YRPPPMLPPS RGGGGGGGGG GSVGGGGGSI GGGGGSSSSS TSRTTTTRSP
PYYTTPRPLL TTSPGQRYRT TTTVRQPVLN PAGGSSSDTN QIPDTNQKAG GRSPPVQVPP
AAAPQPPVPP PQDFCSPRVT ADISWPRTQQ GQTAKQPCPV GTLGVATYVC AAHVGYWNPK
GPDLSNCTSP WVNHIMQKLR SGETAAIVAR ELAEQTKGLL RPGDVPSTVR AMAQLVELLD
VQLRNLTPGG KDSAARSLTK AMVETVNNLL QPRAQAAWRE LPTSEQLHSA TLLLDTVETG
AFMLADNLLK TDTVQETTDN IQLEVARLST DGNLADLTFP QSELHGNSIQ LSASTLKQHG
RNGEIRMAFV LYRNLGSYLS TENASVRLSS EAVYPNYSVI VNSPVITASI NKESNKVYLS
EPVVFTVKHL QHSEENFNPN CSFWSYSKRT MTGFWSTQDC RLLATNRTHT SCSCTHLTSF
AVLMAHVEVK KADSMHDLLL DVITWVGILL SLVCLLICIF TFCFFRGLQS DRNTIHKNLC
ISLFIAESLF LVGINRADQP IACAVFAALL HFFFLAAFTW MFLEGVQLYI MLVEVFESEH
SRTKYFYLAG YGVPAVIVAV SAAVDYRSYG TDRVCWLRLD TYFIWSFIGP ATLIIMLNVI
FLGIALYKMF HHTAILKPDS GCLDNIKSWV IGAIALLCLL GLTWAFGLMY INESTVIMAY
LFTIFNSLQG MFIFIFHCIL QKKVRKEYGK CLRTHCCSGK SVETSISSSS KTTTSRIPGR
YSTGSQSRIR RMWNDTVRKQ ESSFITGDIN SSATLNRVYN NPAVGMYNTQ APYRDTKGIL
NNARDSSVMD TLPLNGNHAN NYSMASSEYL SDCVQILDRS GGYGTHGNHK ETTLEKKILK
ELTSNYIPSY LNNHERATTE RNHNLMNKLV NSSMANGGSM AGGSSSSSSS GVSGCVGSGK
EDNGPMVLDN PAAFPHEENL GLEIIREESN APLLPPRPPP PDSHPPPPPP PHSFSRPRRI
PQETSESFFP LLTNEHTDEH THSPNHRDSL YTSMPVLTDL PDGQMNGLTD GEEESSGELQ
PCKSATAPEL DDVYYKSMPN LGSRNHLHEL QSYYHMGRGG SDGYMVSGSK DESDSSPEEP
PIDPSHLVTS L
//
