ID A0A3Q3KJX1_9TELE Unreviewed; 938 AA.
AC A0A3Q3KJX1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000001053.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000001053.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR AlphaFoldDB; A0A3Q3KJX1; -.
DR STRING; 205130.ENSMAMP00000001053; -.
DR Ensembl; ENSMAMT00000001072.2; ENSMAMP00000001053.2; ENSMAMG00000000531.2.
DR GeneTree; ENSGT00940000161021; -.
DR InParanoid; A0A3Q3KJX1; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13720; PBP2_iGluR_NMDA_Nr3; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF364; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..938
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030080824"
FT TRANSMEM 602..624
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 636..655
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 675..696
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 861..883
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 484..837
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 489..549
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 938 AA; 104040 MW; 2E8E3B63A71AC2BC CRC64;
MVSLSGLWTY CLAPGRPHLL FLTARPLLLL LLLTVFSSPE PCFPHPQPCH ILARIGHTMR
LGALLPTRQP ARIQNALNRA LASLRHQSGG ADPSTTTSQT PPLLPYNLSL EMVARSPAGG
DPESLSRTAC QDLVVRGVSA VLAFPRSREE LIQVEFLSSF LEIPFISILE DTEPLVTKVL
IYFVCNWVSI SWLLCLEGGD GLLSRLQRHN GSTWHLWDII NLTHITVGGD RKEALKILST
RFLRSPSPIS SVLLLGSDPE CLSSVLRAAQ RLAQSLPALQ WIMGYPLSPD SLHTLGGPLG
LLAYGEVGRK PISFYIRDAL QLIGRAVTAA TMVRPDLALI QNMVNCYDKP NRHELPSSGQ
YLARFLSNTS FTGATGLIQV DAGLSRVLSS QLFHVWSLKK GALGQPAWVT VGQWTRGRLE
LEGGIPGLVG GFTRRWRPGL SVEGHRLRVV TLVEHPFVFT REVDEDGLCP AGQLCLDPRT
NRSDIIQGLF NQLHSPNTTT CCYGYCIDLL EKLAEDMGFT FDLYIVGDGK YGALSGTGRW
TGLVGDLLSG AADMAVTSFS INSARSRVID FTSPFYSTSL GILVRSRDTA APIGAFMWPL
HWSMWVGIFV TLHLTALFLT LYEWNSPFGM TPHGRNRLRV FSYSSALNLC YAILFGRTVA
TKTPKCWTGR FLMNLWAIFC LLVLSSYTAN LAAVMVGEKT FEQVSGIHDD KLQHPSLGFR
FGTVRESSAE DYMKKSFPEM HNYMRRFNQP TTPEGVQMLK TDPPALDAFI MDKALLDFEV
SIDADCKLLT VGKPFAIEGY GIGLPQGSPL TRNVSEFVSR YKSDGFMDML HDKWYKVVPC
GKRVFAVTET LQMGIQHFSG LFVLLCMGVG GALLTLAGEH TFYHLVIPRL RRTHTLQYWL
HTSQVSKRCR EGADRPRPKV MKSLIYLPKP LIVIFSLC
//
