ID A0A3Q3KMP7_9TELE Unreviewed; 567 AA.
AC A0A3Q3KMP7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 4-like {ECO:0000313|Ensembl:ENSMAMP00000002737.2};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000002737.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000002737.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q3KMP7; -.
DR Ensembl; ENSMAMT00000002792.2; ENSMAMP00000002737.2; ENSMAMG00000001807.2.
DR GeneTree; ENSGT00940000155765; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF273; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 4 ISOFORM X1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 144..331
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 499..526
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 110..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 65533 MW; BF8CEE3AF6C84A64 CRC64;
MNTLCFYRVP TEKAETSSVK LIESFNYNEH PTIIKTPADL DPRPSHITNE SYLPSNGKEH
SSGKMNGIMQ GNEWSVVNEM GLNDKVGEGK TSRRYGSKYS CHWNQATTEM ERLHEESGGE
QKEKDDDEER GGNEPKDEEN TELKLYMIAS ELLQTERAYV ARLHLLDQVF CSRLTTEAGR
GSFPPEVIRN IFSNISSIYS FHSQFLLPDL ENCISHWNKN PGLGKVLLQH APFMRMYADY
VRNFDQAVAL VRTWTDRSSL FRNIIQDIQS QKVCGSLTLQ HHMLEPVQRI PRYEMLLRDY
LKKLPEDNPD YELAHKSLQT ISMAATHSNS AIHKAERLKR LLEIYEMVGD EDVVNPTNEF
LREGRLLKLA ARNTSAMERH LFLFNNFLLC CTPKFSLVGQ RFTVRCRIGV EGMHVQQTTN
EDHPYTFQVS GKERILELQT RCVHFTLDCI VIYRILVLVA MYIVMQIDTT TFSVEPCRSL
HVFLQAEELG RRAPRWIRDN EVTICMKCQE PFNALTRRRH HCRACGCVKY DGNKMNKVCK
ACYSILTGQR GDRVEDKNKR TEVTLII
//
