ID   A0A3Q3KQU5_9TELE        Unreviewed;       775 AA.
AC   A0A3Q3KQU5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Eukaryotic elongation factor 2 kinase {ECO:0000313|Ensembl:ENSMAMP00000003623.1};
GN   Name=EEF2K {ECO:0000313|Ensembl:ENSMAMP00000003623.1};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000003623.1, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000003623.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q3KQU5; -.
DR   Ensembl; ENSMAMT00000003707.2; ENSMAMP00000003623.1; ENSMAMG00000002426.2.
DR   GeneTree; ENSGT00940000157839; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR   GO; GO:0004686; F:elongation factor-2 kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd16967; Alpha_kinase_eEF2K; 1.
DR   Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR004166; a-kinase_dom.
DR   InterPro; IPR017400; eEF-2K.
DR   InterPro; IPR047588; eEF2K_a_kinase_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR45992:SF2; EUKARYOTIC ELONGATION FACTOR 2 KINASE; 1.
DR   PANTHER; PTHR45992; EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   PIRSF; PIRSF038139; Elongation_factor_2_kinase; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF81901; HCP-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..775
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018768921"
FT   DOMAIN          164..374
FT                   /note="Alpha-type protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS51158"
FT   REGION          51..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          412..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..437
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   775 AA;  87669 MW;  E94F218D7E268CFB CRC64;
     MLLCTRIVLT WLPVQTVSVR PSTHMSVSSL ADTPAGIMED DLMFSMEELG SAKRPAAQQS
     ASSQRASSLT DDDDDDEDDH IICPILDDSS QKRSLYLKNL SNSLPKSNFI YRNDTVAEPQ
     LHKVLSEHAR ETWKHAIEKA KALPDPWAQF HLEDIETEVC IRYRYNAITG EWSQDQVHIK
     VAAQPFGKGA MRECFRTKKL SNFSHSSNWK SASNYVAKRY METVDRNVYF EDVRLQMEAK
     LWGEEYNRHR PPKQVDIMQM CVLEMTNRPG KPLFHLEHYI EGKYIKYNSN SGFVRDDNMR
     LTPQAFSHFT FERSGHQLIV VDIQGVGDLY TDPQIHTEKG TDFGDGNLGV RGMALFFHSH
     LCNKICKSMG LTPFDLSPAE KSQLDCTNKL LKSAQTVLRG CEELCGSPRV RTMSGSRAPP
     LLSRLSETSS ADESMSDVES IPCSPLILPC SPLVAPGSVG KSSLGLSFTG MYEHERLNNN
     NTSEHKESDS GGDSGYPSER RSEGDPNDHI DGAHHRYFRH YSESDEDSVR RLTEEKWSFY
     HSTRAHVHRS SCVATEVERL SSLLQKKIGQ SILGKVHLAM VRYHEAGRFC EKDEQWDQNS
     AMFHMERAAM CGELEAIVAL GQCYLQLPHH ILPDMEAEDN AGNRMKGFKY LLQAAEAGDR
     SSMIIVARAF DTGFNLSADR KQDWKEAIHW YDSVLNMTDY DEGGEFDGTQ DEPRYLLLAR
     EAEMYQVGGY NLTADPQRAG ELFTEAAEAA MAAMKGRLAN QYYMKAEEAW ALMEE
//