ID A0A3Q3KVX8_9TELE Unreviewed; 2572 AA.
AC A0A3Q3KVX8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000001246.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000001246.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR STRING; 205130.ENSMAMP00000001246; -.
DR Ensembl; ENSMAMT00000001273.2; ENSMAMP00000001246.2; ENSMAMG00000000877.2.
DR GeneTree; ENSGT00940000158694; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd18026; DEXHc_POLQ-like; 1.
DR CDD; cd08638; DNA_pol_A_theta; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.20; -; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR046931; HTH_61.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048960; POLQ-like_helical.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF20470; HTH_61; 1.
DR Pfam; PF21099; POLQ_helical; 2.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT DOMAIN 74..253
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 292..519
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 871..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1295..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1440..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1539..1581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1629..1696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1712..1747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1793..1823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1552..1581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1647..1676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2572 AA; 284358 MW; C7650E006AB3BDA9 CRC64;
MKRAKLQHSL QNRSASVLTV PSGLDLSTLS DTLPQPGVWY LLLSSWGLPK PVLERYQKHG
VTHMFEWQAQ CLTVGQVLRG GNLVYSAPTS AGKTLVSELL MLKRVLETKR KALFILPFVS
VAKEKMHYLQ TVFEEAGVRV EGYMGSTSAA GGFTALDVAV CTIEKANSLV NRLIEEDSMS
LLGMVVVDEL HMVGDSGRGY LLELLLTKIR YIAQKQNTTG SLSEGVQIVG MSATLPNLSL
LATWLGAELY QTDYRPVPLQ EHLKVGCNIY DKSLSVVRQF TPALHIKGDD DHIVSLCYET
VREGHSVLLF CPSKNWCEKL VDSIAREFYN LTHTDCEGSM AIQPVCLDQE GLVDVIAQLK
RTPAGLDPIL QRTVPWGVAF HHAGLTFDER DVLEGAFRHG MVRVLAATST LSSGVNLPAR
RVIIRTPTFN GHLLDPLTYK QMVGRAGRKG VDTTGESVLV CKEAERQKGI TLLKGALKPI
SSCLVRREGE GVTTSMLRAI LEIIVGGVAS TPQDVRLYAS CSLLAASMKS DGKNKSNEEH
DKGAIETCVE WLMENEFISI QKDGQGTERY CPTQLGAATL SSSLSPPEAL GIFADLQRAM
KGFVLENDLH ILYLITPLYA EWTTIDWYQF FCLWEQLSSS MKRVAELVGV QEGFLARSVR
GKIVAKTEKQ HRQMAVHKRL FVSFFLLSLH RFFTTLVLQD LVNEVPLGTV ASKYNCNRGQ
LQSLQQSAST YAGMVTVFCK RLGWHNMELL LSQYQTRLSF GVQRELVDLV RVSLLNATRA
RALYAQGLCT VAELARANVA DVEKALRNAV PFKSSKRAVD ESEMEAAERR GIRCVWVTGG
RALTEQEAAT EIVSEARLLL QEDLAQLGVQ WDPTALPPGA PTVNSPDSHH RSDSDSSSGS
CVSSKEAKAS NSKVGDRLKK SESSDTGRHR EVTEEEVKRE KRMTQQKIPM PKEEVRREQG
KSKPLEMEAS RELEEHKKEG RTEAETRQTS SEAPVDTGKV TKIELENTKL YMTNDTDGIR
QEHTRSEEER EECKKPNEKD SEKNEDADSV RPWGQQEKRP IAKKSLTQEL SDIVSSLPQL
LSHAQPLPSP VPCPRFRAPV SRVEQQTSVS TKASTGDGTT GLASSPLQPD RLKHSRALSK
VLHSIQNDKS LQDNTEASCL ASVNNSAPLA KIPASVQVPE PVLQIPHTVS APSNADLNSP
LPASPASVPL FFPEAKRRRV EGREGDKFSS PELFAGEERD EEAKGVAQKG EESFGDSFEL
DTQTERIIGQ QTYQHRDGNG RDRNRLVETE TIKEEEKVET ATEMEIDTDE GRSGSEALDN
ACPRFNISFT DSQMEFFLNT SHQVTDQHHL YNDFKHEIQC NQMFYFCNKK MLLFSQISLG
PAGDGSMGKD KNEGHSDDNG PPDANQVTSE SANRSSSFLF DSLFDSSLLA DLSPHQILDQ
SGEEESNGQD VQDKLPLSST QERRLGNLLA NQEAEKQEAI QWGESSFNLS EWGDSLLVGE
HFLERQSLLR HTERSKKEQE PCDDQAQQPN ADCVLSEQHL PNSQSKPDGG QRGTIKEGES
LKRVEKENKQ ENKKEEKLNV LLSDKDSENT FHCSPGLQEI FDRWPSMSDQ PSQNTASGHK
VTQTVKNPAN AVEAPDLPHP SMQMGRQRGK LNVQSAAAEN DSQLVQCSNH DTENVTERPG
PATDLLPATQ ETPPVTPRVK QTLLPLQKPL TAQPLNQSTP SAVPPQQPAA PKCPKSHPGL
SSHSSEAVPH KAQLTFTFDH HNKHQLGQEP NILPEHDLKS VLCLSSKTKP VLHTDHNLSP
PQDCAAPSSP RPKPPFDTES PVADGFTLQL SQDASLCSSK SGGFSIIDVA SDRRLFDTFI
KEWKTKERYS LALACELREQ GQQPQEEIGG KHMRVSAAHQ KLDSSTDGFP VRDSGGLVLI
GLSVCWGSRD AYYISLQKEQ SLSSSLAAPP LEEDLPVSER LGQVKTCLSK PSANRRGDVV
VTYDIIQVYK TLVLSCGISL EGNCEDPKVA CWLVDPGSDE RTLPNMVTVY CPEELPLLDG
LGNMHAHCPR VRAATKSVLV HAVMNHLTGL LEKDGMLDLF RSIEMPSQVC LALLELNGVG
FSVEECERQK HVMQAKLAAL ESQAYNLAGH SFSLTSIDDI AQVLFLELHL PPNGDVGGSK
NKKTLGYTRR GGGRVRLGKQ FSTTKDVLEK LCPLHPLPGV ILEWRRITNA LTKVVFPLQR
EKKYHHTLAM DRIYPIAQTH TATGRVSFTE PNIQNVPKDF EIYMPVLVGE SPPSQNGFMT
DKIIRSVMPS VAAGTAQGPA FSVSMRHAFI PFSGGMILAA DYSQLELRVL AHLSRDRRLL
QVLNGGADVF RCIAAEWKGV DPDAVNDNLR QQAKQICYGI IYGMGAKSLG EQMGVEENDA
ACYIESFKAR YKGINAFLKE TVKNCIKNGY VQTLMGRRRY LPGITNTNTH IKAHAERQAV
NTTVQGSAAD IVKLATVNIQ KRLRQTYPAA PLSHQHTRSA NNQCRAGTSH LRGGYFVLQL
HDELIYETAE EDLIQVAQIV KREMESAVKL YVKLKAKVKV GPSWGNLQDI DL
//
