ID A0A3Q3L0W1_9TELE Unreviewed; 2072 AA.
AC A0A3Q3L0W1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Nuclear receptor corepressor 2 {ECO:0000313|Ensembl:ENSMAMP00000007152.2};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000007152.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000007152.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR STRING; 205130.ENSMAMP00000007152; -.
DR Ensembl; ENSMAMT00000007349.2; ENSMAMP00000007152.2; ENSMAMG00000004870.2.
DR GeneTree; ENSGT00940000159022; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 421..472
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 594..645
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 597..641
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 598..645
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1433..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1912..1932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1948..2072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1074
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1433..1455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1591..1615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1616..1645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1653..1673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1741..1760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1975..1992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1999..2014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2027..2045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2072 AA; 229306 MW; AAB7D0EBE1E923BC CRC64;
MSSHSQSVPP GRRTGLDTRH LPNPATLPLQ LQRAHTEVGL VDYHSHHARD YSSHLAQPHR
RRPSLLSEFQ PGNERGQEQH IRYEHIYLPE ASSQSDVEYA EIKRPRLDMG PDTVMRPSSH
RTPLPLGAVE DMSKERGSAM GKLEPISPVS PDHMDPDLDL VPARFSKEEL IQNMDRVDRE
ITMVEQQICK LRKKQQQLEE EAAKPHEPER PISPPPSEAK HRSLVQIIYD ENRVSRAQTH
TTCSICGLPL YNQPSDTKQY HENIKINQAM RKKLILYFKR RNHARKQWEQ KFCQRYDQLM
EAWEKKVERI ENNPRRRAKE SKVREYYEKQ FPEIRKQREL QERMQSRVGQ RGGGLTSTAA
RSEHEVSEII DGISEHENTE KQMRQLAVIP PMLFDAEQQR IKFINMNGLM DDPMKVYKDR
QVMNMWSEQE KDTFREKFIQ HPKNFGLIAS FLERKTVAEC VLFYYLTKKN ENYKNIVRRN
YRRRGRSQVF LSLQHSQQQQ QQVNRSSQED KEEKEKEGER DEEKHEAEDK EDGMKDDTSG
EDAEDKEPTV AFKGRRTANS QGRRKGRITR SMTSEVEETT TPPLNNELAN LEMNESSRWT
EEEMETAKKG LLQYGRNWSA IAKMVGSKTV SQCKNFYFNY KKRQKLDEIL QQHKMKSEKE
RKARRRGKAL QNEEASTPYA AEEEMMEGSG ASGNEEEAPE DGEGTPPGSN NSSDTESLPS
PHSSEDSKAQ EEGSSRSKAS SNSGDKEASR SDMGQADDEK PPVKEEVDST IKQEIKTETG
EPNKEQPAQP SDATDRKPPT AETEEVKSTT KSSKKDHGAK TGSHGDSDSS ATCSADEVEE
TDSTDKNRMT SPRPSLLNYT HDGVISSPLQ KPMDLKQLKQ RAAAIPPIVS HSSIPAVQGG
SITKGIPGTR MHPDSSVSYR GGSITQGTPA DVLYKGTITR LITEDSASRA ERERDEQVSK
GHVVYEGISG HILTYDRAAS QTPKDEGRVP GHPGEILGLK RSYDAMEGGI SRGLPVRDSL
SAANCEGLIG RAMPHDRDSP HHHHIRGSIS QGIPRHLDPQ DGYLRREAKQ MKREGSPPRG
PSALSDQVKG REAMVTTVKE GGRSIHLIPR EELRQPAKEG IIAQGTPMKQ DAAGSGKRHD
VRSIIASSPR SYHNTPSHLE IRADRGRYEE APKGRPSAVV STASPIARSS PLTLGSEQGS
KAHHSPVGYE DKGALRTPYP GPSHRGSPLS REASQRQHDG SSKNQPQERK ATPTPRELNA
TKSPLPGVPD QQTYERLLQG LGAADLFHQI PLTFDPAALP RGIPIDPAAY YLPRHLTPNP
AYPHPYPYLI RGFPDTAALE NRQTLLNDYI TSQQMHQWPA AAAMTAPRSD LLRGLTPRDQ
PLPLPYSAAP RGIIDLSQVP HLPVLVPPSA GTAGSPMDRI TYIPGGSATF PGRPYNTSPI
SPVGSSHLNK MQGTSSSSDR ERERDREQRD REKGGSLGNV EHAPIWRPGV EQISSCSSSV
RPASQPYSHQ HSPVSPRNQE NVQQRPSVLH NTGGKSLSVS EHSSSSCVFV WPVRSMPSGP
TRIQGYSGHL QRTGLPPEAY SPAMDSSVAK EQSRDGGKNR GGLPKHGHDQ HGPSSKSDPK
LSSPSSGGIY PGSYTSASSR PQHLLPPQLD SAPGRGESST PSREKTQNKP MSIQEQELRA
LGKTTMTAAN FINAIIMRQI SCETGMPETG SLVASSYDRQ CCPISDVALS LNKQEVITKD
YTRQSQQQSY HSSPVLDLTR PPSASQPPPT SQESIPPMKR DLSINIYVPT FWIPTILIVL
WELMLTRFLF PLSRMGSRSP PNASQPPAFF SKLTESTSAI VKSKKQEMIK KMTVVGNDGD
FNSGQPGTEI FNMPASTNAG PMSVRSNPVP EAPGNSKGLE AIIRKALMGR YDDQPEERSP
SNTSNPMGSS VSAGIPLVDV RAEDFFLQGG KSSKGSGRSN GRKAKSPGPG LSGGERPSSV
SSVHSEGDCN RRTPLTSRML EDRPSSTGST PTPFPCNPLI MRFPSGTVSA PSPSSGQSGG
QVPGSGPGQG RSWEDEPKPL LMSQYETLSD SE
//
