ID A0A3Q3L0Z4_9TELE Unreviewed; 871 AA.
AC A0A3Q3L0Z4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000003424.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000003424.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; A0A3Q3L0Z4; -.
DR STRING; 205130.ENSMAMP00000003424; -.
DR Ensembl; ENSMAMT00000003505.2; ENSMAMP00000003424.2; ENSMAMG00000002304.2.
DR GeneTree; ENSGT00950000182815; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 156..236
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 460..601
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 871 AA; 96031 MW; D2FE1AB7E1A2C1F4 CRC64;
MQCACLGLGG AGGAGHFTSL NPSHLPERGA RGEALQHGQS GTLPHFLEEP VDAYIVKSNP
IKLRCQARPA LQIFFKCNGE WVHQSQHMSQ EHTDLRTGLK IREVMINVSR QQVEDFHGPE
DYWCLCVAWS HLGTSKSRKA TVRIAYLRKN FEQDPQGTEV PLNGMIVLHC RPPEGVPLAE
VEWLKNEEPL SSDGVVDARG DHNLIISEAR LSDSGNYTCV ASNIVAKRRS ATATVVVYVD
GGWGEWSMWS ACSSDCERQR SRDCTAPEPK HGGRLCDGVA LATDNCTGGL CTQSVENSSD
VALYSGLAAG VVTVVLLIIA VTLYRRSQSE YGVDVIDSSA LTGGFQSFSF KTSHQANPLL
INSSMQPDLT VSRTYTSPMC FQDSIDKELM AEHSLLDPLP DLKVKGVAER AEYHVMSHPQ
TFPRGLAPDY RGVAMGTTLG RRSKNLFTTQ VSLTPSRPLH KATAVFGQAG GRLVVPNTGI
SLLVPHGGIA EDTTWEMYMI INQQDSSTVT QDEPEIFLSP AVTYGPPGLD LSCPIAMTIA
HCAEVSADNW TVRLKRQMQD NKWEEVISVD EESTSCYCLL EAHRCHVLLE HPGCYALVGE
PLNQEAAKRL RLAVFGSPDT CNSLGFTLRV YCVDDTPHAF QEVATGERSR GGRLLEEPKM
MLFRGNTFSL QVSIQDIPQL LWNIKPFTTC QEFSFSQVWA SNQRPLQCAF PLERYSHSSS
QLSCKISVRQ VKGEEQILQV YTSVVENEKG VVPFFTQSDC TITSQTGSRA FKIPLSIRQR
ISATFDTANA KGKDWQLLAQ KLHIDRNLCY FACQESPSSV ILSLWEAQHQ DLGDLDSLAS
ALEEIGKVQS TRIATLGCTR EEQDSEFTKL G
//