ID   A0A3Q3L0Z4_9TELE        Unreviewed;       871 AA.
AC   A0A3Q3L0Z4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000003424.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000003424.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR   AlphaFoldDB; A0A3Q3L0Z4; -.
DR   STRING; 205130.ENSMAMP00000003424; -.
DR   Ensembl; ENSMAMT00000003505.2; ENSMAMP00000003424.2; ENSMAMG00000002304.2.
DR   GeneTree; ENSGT00950000182815; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 1.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW   ECO:0000256|RuleBase:RU367033}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          156..236
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          460..601
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
SQ   SEQUENCE   871 AA;  96031 MW;  D2FE1AB7E1A2C1F4 CRC64;
     MQCACLGLGG AGGAGHFTSL NPSHLPERGA RGEALQHGQS GTLPHFLEEP VDAYIVKSNP
     IKLRCQARPA LQIFFKCNGE WVHQSQHMSQ EHTDLRTGLK IREVMINVSR QQVEDFHGPE
     DYWCLCVAWS HLGTSKSRKA TVRIAYLRKN FEQDPQGTEV PLNGMIVLHC RPPEGVPLAE
     VEWLKNEEPL SSDGVVDARG DHNLIISEAR LSDSGNYTCV ASNIVAKRRS ATATVVVYVD
     GGWGEWSMWS ACSSDCERQR SRDCTAPEPK HGGRLCDGVA LATDNCTGGL CTQSVENSSD
     VALYSGLAAG VVTVVLLIIA VTLYRRSQSE YGVDVIDSSA LTGGFQSFSF KTSHQANPLL
     INSSMQPDLT VSRTYTSPMC FQDSIDKELM AEHSLLDPLP DLKVKGVAER AEYHVMSHPQ
     TFPRGLAPDY RGVAMGTTLG RRSKNLFTTQ VSLTPSRPLH KATAVFGQAG GRLVVPNTGI
     SLLVPHGGIA EDTTWEMYMI INQQDSSTVT QDEPEIFLSP AVTYGPPGLD LSCPIAMTIA
     HCAEVSADNW TVRLKRQMQD NKWEEVISVD EESTSCYCLL EAHRCHVLLE HPGCYALVGE
     PLNQEAAKRL RLAVFGSPDT CNSLGFTLRV YCVDDTPHAF QEVATGERSR GGRLLEEPKM
     MLFRGNTFSL QVSIQDIPQL LWNIKPFTTC QEFSFSQVWA SNQRPLQCAF PLERYSHSSS
     QLSCKISVRQ VKGEEQILQV YTSVVENEKG VVPFFTQSDC TITSQTGSRA FKIPLSIRQR
     ISATFDTANA KGKDWQLLAQ KLHIDRNLCY FACQESPSSV ILSLWEAQHQ DLGDLDSLAS
     ALEEIGKVQS TRIATLGCTR EEQDSEFTKL G
//