ID A0A3Q3L1D7_9TELE Unreviewed; 591 AA.
AC A0A3Q3L1D7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Neurofibromin 2a (merlin) {ECO:0000313|Ensembl:ENSMAMP00000007327.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000007327.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000007327.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A3Q3L1D7; -.
DR STRING; 205130.ENSMAMP00000007327; -.
DR Ensembl; ENSMAMT00000007530.2; ENSMAMP00000007327.1; ENSMAMG00000004984.2.
DR GeneTree; ENSGT01020000230354; -.
DR InParanoid; A0A3Q3L1D7; -.
DR OrthoDB; 5476297at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13194; FERM_C_ERM; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR041789; ERM_FERM_C.
DR InterPro; IPR046810; ERM_helical.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23281:SF23; MERLIN; 1.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF20492; ERM_helical; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PIRSF; PIRSF002305; ERM; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT DOMAIN 22..311
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT COILED 313..415
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 441..471
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 515..552
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 76..79
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol)"
FT /ligand_id="ChEBI:CHEBI:57880"
FT /evidence="ECO:0000256|PIRSR:PIRSR002305-1"
FT BINDING 294
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol)"
FT /ligand_id="ChEBI:CHEBI:57880"
FT /evidence="ECO:0000256|PIRSR:PIRSR002305-1"
SQ SEQUENCE 591 AA; 69533 MW; 68A2E84F31B953FC CRC64;
MASALAAKMG FNSLMRKQAR NFNVRICTME SDMEFSCEVK WKGKDLFDLV CRTLGLRETW
FFGLQYNIKD TVAWLKLEKR VLDQEVPKEE PITFHFLAKF YPENAEEELV QDITQHLFFL
QVKKKILEEE IHCPPEASVL LASYAVHAKY GDYDPNIHKP GFLAEEELLP KRVINLYQMT
AEMWEERITA CYAEHRGRTR DEAEMEYLKI AQDLDMYGVN YFLIRNKKGT DLLLGVDALG
LHIYEPENRL TPKCSFPWNE IRNISYSDKE FTIKPLDKKT NVFKFNSSRL RVNKLILQLC
IGNHDLFMRR RRVDSLEVQQ MKAQAREERA RKQVERQRLQ REKQLREEAE RARDELERRL
IQLQDEAHMA NEALLRSEQT ADLLAEKAQI AEEEAKLLAQ KAAEAETEMQ RIKVSAIRGQ
EERRLMEQKM LEAEMLALKM AEESERRAQE AEQLKQDLQE ARESERRAKH KLLEITSKAV
YVSPGLPPDN MPPDVSFSRE NLSFDFKDTD MKRLSMEIEK EKVEYMEKSK HLQEQLNELK
TEIESLKLKE RETPLDIIHN QNTEQGTSKH SNFKKLTLQS TKSRVAFFEE L
//