ID A0A3Q3L5N5_9TELE Unreviewed; 837 AA.
AC A0A3Q3L5N5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 {ECO:0000313|Ensembl:ENSMAMP00000009263.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000009263.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000009263.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR AlphaFoldDB; A0A3Q3L5N5; -.
DR STRING; 205130.ENSMAMP00000009263; -.
DR Ensembl; ENSMAMT00000009509.2; ENSMAMP00000009263.1; ENSMAMG00000006264.2.
DR GeneTree; ENSGT00940000158956; -.
DR InParanoid; A0A3Q3L5N5; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08854; ArfGap_AGAP1; 1.
DR CDD; cd04103; Centaurin_gamma; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF3; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 334..559
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 580..704
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 747..779
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 240..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 90810 MW; 4DDAED112BC7FDC9 CRC64;
MNNNSKSVNS TAIKVEIKRH ESLQSAINKL SKQFERVEDK QLRSGLKVYL HSIQVNIANS
QEWTLSRSIP ELRLGVLGSL KSGKSALVNR YITSSYAALE KADGGRYKKE VLVDGQSHLL
LIREEAGQPD AQFSSWVDAV ILVFSLENEA SFQELYQLYS QLSAYRTDIP VIVVGTQDKI
SSTNPRVIED QRARQLCIDV RHSLFYETCA TYGFNVDRVF SEAAQKIVAQ KKQAALQACK
SLPNSPSHSG GSTPGSASFP GQTINGPSSG YAYSLPSTPV VSHRELRVAQ GEGAGSVSSR
SLKSIPRRPS LFKNRDTDKK AGDPKGDLSS VRGVPIKQSI LWKRSGSSLN KEWKKKYVTL
SNNGTLSYHS SSSDYTQNIH GKDIDLLRVT VKVPGKRPPR AVVPAGPSLV PPSSVPGVNG
LSKELIAADN TSTVPQLCPA TLSVVDDRSG ALSPQGGERG LQRCPSSLST KAQSVDALEG
TASPFAGKEP SQSSPMSDRK KNRRKKSMNQ KGDAAVGQAE EEENADFIIV SFTGQTWHFE
AQSLEERDSW VSAIESQILA SLQSCESGRN KARRSSQSEA VALQAIRNAK GNSLCVDCEA
PNPTWASLNL GALICIECSG IHRNLGTHLS RVRSLDLDDW PGELTQVLAA IGNHMANSIW
ESCTQGRIKP SPNATREERE SWIRAKYEQR AFVAPLLPAL GTQMPDDGMP VWLLSAVTDK
DLPRLLLLLA HSTKEQINAQ PAGSTSSPRT ALHAACQLGD VVMTQLLVWY GIDMKAKDNQ
GQTAMMLARK TGSKGCIDIL LQHGCPSETS PTTVTPALSR RSSTASLGRT SSRKRVS
//