ID A0A3Q3L669_9TELE Unreviewed; 648 AA.
AC A0A3Q3L669;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Growth arrest-specific 6 {ECO:0000313|Ensembl:ENSMAMP00000005109.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000005109.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000005109.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC {ECO:0000256|ARBA:ARBA00008850}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q3L669; -.
DR STRING; 205130.ENSMAMP00000005109; -.
DR Ensembl; ENSMAMT00000005242.2; ENSMAMP00000005109.1; ENSMAMG00000003445.2.
DR GeneTree; ENSGT00940000154035; -.
DR InParanoid; A0A3Q3L669; -.
DR OrthoDB; 19806at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 4.10.740.10; Coagulation Factor IX; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR035972; GLA-like_dom_SF.
DR InterPro; IPR000294; GLA_domain.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24040:SF14; GROWTH ARREST-SPECIFIC PROTEIN 6; 1.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00594; Gla; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00001; GLABLOOD.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00069; GLA; 1.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57630; GLA-domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS00011; GLA_1; 1.
DR PROSITE; PS50998; GLA_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Gamma-carboxyglutamic acid {ECO:0000256|ARBA:ARBA00022479};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..648
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018755253"
FT DOMAIN 41..87
FT /note="Gla"
FT /evidence="ECO:0000259|PROSITE:PS50998"
FT DOMAIN 109..147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 149..188
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 285..462
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 469..641
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 118..135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 137..146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 614..641
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 648 AA; 72224 MW; D0D97A048547304D CRC64;
MRLSPTKSLQ WAALLVLVVR WSDSISLCPE EANQFLSRHR RANQVFEETK QGHLERECVE
ERCTKEEARE VFENDPETDY FYPRYLACIT KFGDSEKKKQ DLVTCVHNIP DQCSSSPCNA
EGTVRCEDKK GDFLCHCFTG WAGARCEKDV DECRKRNGGC DHECNNTMGS YRCSCHQGYM
LVGRHMCSDV DECEDPGVCG TAQCENKEGS YDCLCDIGYV YDNETTSCVD VDECETGVCA
EECLNTPGSF RCFCDGRQGM KLGQDLRSCK PVTPCMSPSL KRNSRSLYLG RMFSGVPVVR
LRFRRRIHTG FSAEFDFRTY DPEGVIFFAG GHLNSSWIVL AMHHGKLELQ LKYGSVSRVT
SSGPIVSDGQ WRKISVEEQG RSLVIKIDRE AVMKIAVNGD LFTLQKGMHE LNLTVGGVPF
REDGLVNQIN PRLDGCMKEW RWLTGEDTSI QETIQSNDNM QCFSTEDPGA YYPGTGFALF
NISYESQNLS IKLILRPTSG IGVLFALIHQ DRVPLSIALA DYHPITDEWR DFVLVSAGDV
IIASSPAPLC DGDSHEIKVT IKGNQTLLLV DGQSGRSEDI EIPTDLLSQS STFIGGLPDV
PLVSTLVSAP YSGCMEVSVN GQSLDLDQAI HKHNDIRSHS CPLLDSHQ
//
