ID A0A3Q3L7A1_9TELE Unreviewed; 1115 AA.
AC A0A3Q3L7A1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Regulator of nonsense transcripts 1-like {ECO:0000313|Ensembl:ENSMAMP00000009272.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000009272.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000009272.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q3L7A1; -.
DR STRING; 205130.ENSMAMP00000009272; -.
DR Ensembl; ENSMAMT00000009519.2; ENSMAMP00000009272.1; ENSMAMG00000006229.2.
DR GeneTree; ENSGT00940000157413; -.
DR InParanoid; A0A3Q3L7A1; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 94..251
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 43..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..134
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 116..144
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 162..192
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 977..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1115 AA; 123223 MW; 3C5CB454206DC6E7 CRC64;
MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEYDFTDFTL PSQTQTQGQT QSQLDSQING
PDGVLQNGDD PVVKASQLLA ELNFEEDEED AYYTKDLPVH ACSYCGIHDP ACVVYCNTSK
KWFCNGRGNT SGSHIVNHLV RAKSKEVTLH KDGPLGETVL ECYNCGCRNV FLLGFIPAKA
DSVVVLLCRQ PCASQSSLKD INWDSSQWQP LIQDRCFLSW LVKIPSEQEQ LRARQITAQQ
INKLEELWKE NPTATLEDLE KPGVDEEPQH VLLRYEDAYQ YQNIFGPLVK LEADYDKKLK
ESQTQDNITV RWDLGLNKKR IAYFTLPKTD SDMRLMQGDE ICLRYKGDLA PPWKGIGHVI
KVPDNYGDEI AIELRSSVGA PVEIPHNFQV DFVWKSTSFD RMQSALKTFA VDETSVSGYI
YHKLLGHEVE DVVIKCQLPK RFTAQGLPDL NHSQVYAVKT VLQRPLSLIQ GPPGTGKTVT
SATIVYHLAR QGNGPVLVCA PSNIAVDQLT EKIHQTGLKV VRLCAKSREA IDSPVSFLAL
HNQTRNMDSM PELQKLQQLK DETGELSSSD EKRYRALRRT AERELLMNAD VICCTCVGAG
DPRLAKMQFR SILIDESTQA TEPECMVPVV LGAKQLILVG DHCQLGPVVM CKKAAKAGLS
QSLFERLVVL GIRPIRLQVQ YRMHPALSAF PSNIFYEGSL QNGVTAADRM KKGFDFQWPQ
PDKPMFFYVT QGQEEIASSG TSYLNRTEAA NVEKITTRLL KAGAKPDQIG IITPYEGQRS
YLVQYMQFSG SLHTKLYQEV EIASVDAFQG REKDFIILSC VRANEHQGIG FLNDPRRLNV
ALTRARYGVI IVGNPKALSK QPLWNHLLNY YKEQKVLVEG PLNNLRESLM QFSKPRKLVN
TINPGGRFMS TAMYDAREAL IPGSVYDRSN NGRTSNMYFQ THDQIGMIGT GPSPMTSMNI
PIPFNLVMPP IPPPGYMGQV NGPTAGRGGG MKGKAGSGGG GGTRGGRQRN RGNTGNHGGG
NGGGDRGHGG HMTGSQASQD LGSQAFSQGP LTQGYINMSQ PSQMSQPGLS QPELSQDSYL
GDEFKSQIDV ALSQDSTYQG ERAYQHGGVT GLSQY
//