ID A0A3Q3L7K0_9TELE Unreviewed; 851 AA.
AC A0A3Q3L7K0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR005813};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000005576.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000005576.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR005813}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR005813}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|PIRNR:PIRNR005813}.
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DR AlphaFoldDB; A0A3Q3L7K0; -.
DR STRING; 205130.ENSMAMP00000005576; -.
DR Ensembl; ENSMAMT00000005732.2; ENSMAMP00000005576.2; ENSMAMG00000003745.2.
DR GeneTree; ENSGT00550000074897; -.
DR InParanoid; A0A3Q3L7K0; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0032301; C:MutSalpha complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|PIRNR:PIRNR005813};
KW DNA repair {ECO:0000256|PIRNR:PIRNR005813};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR005813};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005813};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT DOMAIN 671..687
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 851 AA; 95555 MW; 65BA092B2224990D CRC64;
MSEFVLNGGS FKHNGGTSVR LHTFCIPGSA EAKHDKTTSS HPVLIQVSRV CHSHFFFIAT
SCSSGATTSG ASMIVALVEG RGLARGEIGM ASLNLKCPEL VLSQFADTGT YAKVITKIHI
LVPLEILMPD TATEKGKGTK LFNLITENFP GVAFTAIQRK YFNERKGLEY IQQLCAPEFG
TVLMEVQAKY YCLASAAALL KYLEFIQNSV YAAKSLKVSF KGSEQTAMID TASAMHLELV
VNNRDHRSEH TLLGVLNHTK TPSGARRLRS NILEPLVDVD TINIRLDTIQ ELLQNEELFF
GLKNVIGHFL DIDQLLSVLV QIPKQETVQV AEAKITHVIQ LKHTLDLVPR LRMALKNCNT
ALLKAYSTSL EDNRFDMILE QIKTVINDDT TYLKGSLNMR TQKCYAVRPN VNEFLDIARR
AYTEIVDDIA GLVNQMGERY GLPMRTSFST ARGFFIQMKL EGVILPAGKL PSEFIKVTKQ
KNNYGFTTAD LMKMNDRCDE ALREIFHMSY VVICQLLRTI HEHIHCLYKL SEAVSMLDML
LSLANACTLS DYVRPEFTDT LAIKQGRHPI LERIVGQQPV SNNTYISEGS NFVILTGPNM
SGKSTYLKQV ALCQIMAQIG SFVPAEYASF RVADQIFTRI GVDDDFETNS STFMLEMKEI
SYILHNVSDR SLIIIDELGR GTSAEEGIGI CHSVCEFLLS LQAFTLFATH FLELCQLESL
YPNVENQHME VQHIRSGDTG AESVVYTYLL NRGCAEERHY GLRAAEMTAL PSRIIQEAKE
ISIRVSQQLL ANHYSDPETQ MQRALYHLAT RLLQAARNSR LDPDSLRMYL KGLRKQYEAE
LQVPQIYWRS P
//
