ID A0A3Q3LAH3_9TELE Unreviewed; 101 AA.
AC A0A3Q3LAH3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Gastric inhibitory polypeptide {ECO:0000256|ARBA:ARBA00013490};
DE AltName: Full=Glucose-dependent insulinotropic polypeptide {ECO:0000256|ARBA:ARBA00031537};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000010317.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000010317.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potent stimulator of insulin secretion and relatively poor
CC inhibitor of gastric acid secretion. {ECO:0000256|ARBA:ARBA00002766}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR AlphaFoldDB; A0A3Q3LAH3; -.
DR STRING; 205130.ENSMAMP00000010317; -.
DR Ensembl; ENSMAMT00000010582.2; ENSMAMP00000010317.1; ENSMAMG00000006961.2.
DR GeneTree; ENSGT00940000177404; -.
DR InParanoid; A0A3Q3LAH3; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0042304; P:regulation of fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0050796; P:regulation of insulin secretion; IEA:InterPro.
DR GO; GO:0009749; P:response to glucose; IEA:InterPro.
DR Gene3D; 6.10.250.590; -; 1.
DR InterPro; IPR039078; GIP.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR15211:SF0; GASTRIC INHIBITORY POLYPEPTIDE; 1.
DR PANTHER; PTHR15211; GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE; 1.
DR Pfam; PF00123; Hormone_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..101
FT /note="Gastric inhibitory polypeptide"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018571292"
FT DOMAIN 37..64
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|Pfam:PF00123"
SQ SEQUENCE 101 AA; 11693 MW; 6BC559717E513FF7 CRC64;
MKVLLFELLV ICTVGALLSE ANAQPEEMGF HHVGRRYAES TIASEISKIM DSMVQKNFVE
FLLNQKHKRS KYVAAYEGDP EEPQYNELLR LHVQEKQRTK L
//
