ID A0A3Q3LBX2_9TELE Unreviewed; 226 AA.
AC A0A3Q3LBX2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Mitochondrial fission factor {ECO:0000256|RuleBase:RU368040};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000007201.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000007201.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in mitochondrial and peroxisomal fission.
CC Promotes the recruitment and association of the fission mediator
CC dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
CC {ECO:0000256|RuleBase:RU368040}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
CC Mitochondrion outer membrane {ECO:0000256|RuleBase:RU368040}; Single-
CC pass type IV membrane protein {ECO:0000256|RuleBase:RU368040}.
CC Peroxisome {ECO:0000256|RuleBase:RU368040}.
CC -!- SIMILARITY: Belongs to the Tango11 family.
CC {ECO:0000256|ARBA:ARBA00009806, ECO:0000256|RuleBase:RU368040}.
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DR AlphaFoldDB; A0A3Q3LBX2; -.
DR STRING; 205130.ENSMAMP00000007201; -.
DR Ensembl; ENSMAMT00000007399.2; ENSMAMP00000007201.2; ENSMAMG00000004895.2.
DR GeneTree; ENSGT00390000009776; -.
DR InParanoid; A0A3Q3LBX2; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0000266; P:mitochondrial fission; IEA:UniProtKB-UniRule.
DR GO; GO:0090141; P:positive regulation of mitochondrial fission; IEA:UniProtKB-UniRule.
DR GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:UniProtKB-UniRule.
DR InterPro; IPR039433; Mff-like_dom.
DR InterPro; IPR008518; Mff/Tango-11.
DR PANTHER; PTHR16501:SF17; MITOCHONDRIAL FISSION FACTOR; 1.
DR PANTHER; PTHR16501; UNCHARACTERIZED; 1.
DR Pfam; PF05644; Miff; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368040};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU368040};
KW Mitochondrion outer membrane {ECO:0000256|RuleBase:RU368040};
KW Peroxisome {ECO:0000256|RuleBase:RU368040};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368040};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368040}.
FT TRANSMEM 206..224
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368040"
FT DOMAIN 13..155
FT /note="Mff-like"
FT /evidence="ECO:0000259|Pfam:PF05644"
FT DOMAIN 157..226
FT /note="Mff-like"
FT /evidence="ECO:0000259|Pfam:PF05644"
FT COILED 177..204
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 226 AA; 25972 MW; 7D11D44E8083A627 CRC64;
MNGAEFPSPT AEMAEMNRIQ YELEYTEGIS QKMRIPEMLK VAPQDHDDHN VGSQEVPLSV
IMQVPERIVI SGDSNDPQFS RPRDLDLIQS TPLETLSLKT PPRVLTPLDF LEDEQRTALD
TEEVLRPQGR LRREHSASEN AAIRHNSQLM RNDSALALST YEATLDGGPD DMTVIDATTL
RRQLIKLNRR LQHLEEENKE RAKREMILYS VTVAFWLINT LVWLRR
//
