ID A0A3Q3LCW2_9LABR Unreviewed; 195 AA.
AC A0A3Q3LCW2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Vasoactive intestinal peptide {ECO:0000313|Ensembl:ENSLBEP00000006735.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000006735.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000006735.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
CC stimulates myocardial contractility, increases glycogenolysis and
CC relaxes the smooth muscle of trachea, stomach and gall bladder.
CC {ECO:0000256|ARBA:ARBA00002470}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR AlphaFoldDB; A0A3Q3LCW2; -.
DR STRING; 56723.ENSLBEP00000006735; -.
DR Ensembl; ENSLBET00000007074.1; ENSLBEP00000006735.1; ENSLBEG00000005194.1.
DR GeneTree; ENSGT00950000183154; -.
DR InParanoid; A0A3Q3LCW2; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR Gene3D; 6.10.250.590; -; 2.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF5; VIP PEPTIDES; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660}.
FT DOMAIN 74..96
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
SQ SEQUENCE 195 AA; 22435 MW; A514559A689365FD CRC64;
HTCRDLPRRL LLIEHDVYSR CLLVVLRRPS RHADGLFTSG YSKLLGQLSA RRYLESLIGK
RVSDELMDEP VKRHSDAIFT DNYSRFRKQM AVKKYLNSVL TGKRSLEDPV ASDPEDSMDE
PNTFQDSYSD INVDHLLNNF QLVGTNTQKK KVYSYSIVAL INKMHSIDIK MYLNAPVKSF
MLVMKLTESD TDVSL
//
