ID A0A3Q3LGU0_9TELE Unreviewed; 858 AA.
AC A0A3Q3LGU0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000008629.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000008629.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC Pro nor hydroxyproline.; EC=3.4.14.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001257};
CC -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC {ECO:0000256|ARBA:ARBA00010036}.
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DR AlphaFoldDB; A0A3Q3LGU0; -.
DR Ensembl; ENSMAMT00000008854.2; ENSMAMP00000008629.1; ENSMAMG00000005830.2.
DR GeneTree; ENSGT00940000158174; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR045785; Dpp_8/9_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF19520; Dpp_8_9_N; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT DOMAIN 32..158
FT /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19520"
FT DOMAIN 198..592
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 685..855
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 858 AA; 97379 MW; E22D654B6BC9EFF0 CRC64;
MHRVKKVKLC DNKEGIWKSC VTVSMTAVDG LADSTEVVEM EDVPCQFFVE KHSWEGLRDI
IHCSRKYSGM IANKAPHDFQ FVQKKDENGP HSHRLYYLGM PYGSRENSLL YSEIPKKIRK
EALLVLSWKQ MLDHFQATPH QGAYSREEEL LRERKRLGAF GITSYDYHPQ TGMFLFQASN
SLFYCQDGGN NGFIQSAPVK PVDIKTQCSG TRMDPKICPG DPDFIAFINN NDLWIANIKT
GEERKLTYCH KGMDNVKEDP KSAGVATFVI QEEFDRFTGY WWSPSAVEDP SGGKTVYLLY
EEVDETEVEI IHVPSPALEE RKADAYRYPR TGSKNPQATL KLAEIKTDHQ GRIVSTQDKE
LVIPFTSLFP GTEYIARAGW TSDGKYGWAV LLDRSQRKLQ LVLLPPALFI PVTDDPALRQ
ESLEAVPSDT QPYIIYEETT DVWINVNDIF YPFIQTTEDE FTFIWVNESK TGFSHLYKIT
SLLQPGCYHW TEGYQHGDGD FKCVIKEEVP LTSGEWEVLA RHGSKIWVNE AAKLVYFQGT
RDTPLEHHLY VVSYDSPGDV VRLTKPGFSH SCSVSQNFDF FISHYSNVST PPCVHVYKLS
RSEGDPLHIV PEFWASMMES TGCPGDYSPP EIFDFPGKSG FQLYGMVYKP HNLQPGRKHP
TVLFVYGGPQ VQLVNNSFKG MKYLRLNTLA SLGYAVVVID GRGSCQRGLE FEGALKNKMG
QVEIEDQVEG LQYVAEKFNF VDLSRVAIHG WSYGGFLSLM GLIQRPNIFK LAIAGAPVTV
WMAYDTGYTE RYMDVPENNQ QGYEEGSVAL HVDKLPSEPN RLLILHGFLD ENVHFFHTNF
LVSQIIRAGK PYQLQSCT
//
