ID A0A3Q3LHI8_9TELE Unreviewed; 385 AA.
AC A0A3Q3LHI8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Guanine nucleotide binding protein (G protein) alpha 12a {ECO:0000313|Ensembl:ENSMAMP00000012697.1};
GN Name=GNA12 {ECO:0000313|Ensembl:ENSMAMP00000012697.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000012697.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000012697.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
CC {ECO:0000256|ARBA:ARBA00010405}.
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DR AlphaFoldDB; A0A3Q3LHI8; -.
DR STRING; 205130.ENSMAMP00000012697; -.
DR Ensembl; ENSMAMT00000013038.2; ENSMAMP00000012697.1; ENSMAMG00000008602.2.
DR GeneTree; ENSGT00940000157636; -.
DR InParanoid; A0A3Q3LHI8; -.
DR OrthoDB; 2897309at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000469; Gprotein_alpha_12/13.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF130; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00440; GPROTEINA12.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 16..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 44779 MW; 81DA11C18C1767F4 CRC64;
MSGVVRTLSR CLLRADASRD PGSSKERSRE RDAAQEREAR RRSREIDAML ARERRAVRRL
VKILLLGAGE SGKSTFLKQM RIINGQEFDQ KALLDFRDTI YENILKGMRV LVDARDKLGI
SWQCCENEKQ GMLVMSWEGR VGASGVEPSE FQLYVMALSA LWADSGIQEA YSRRSEFQLS
ESVKYFLDNL DRIGQLNYIP SKQDILFARK ATKGIVEHDF VIKKIPFKMV DVGGQRSQRQ
KWFQCFDGIT SILFMVSSSE YDQVLMEDRR TNRLVESMNI FETIVNNKLF LNVSIILFLN
KTDLLVEKIR TVDIRKNFPE FRGDHRRLED VQAFLVQSFS RKRRNRGKPL FHHFTTAVDT
ENIRFVFHAV KDTILQENLK DIMLQ
//
