ID A0A3Q3LJF1_9TELE Unreviewed; 1399 AA.
AC A0A3Q3LJF1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Intersectin 1 (SH3 domain protein) {ECO:0000313|Ensembl:ENSMAMP00000014253.2};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000014253.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000014253.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR Ensembl; ENSMAMT00000014644.2; ENSMAMP00000014253.2; ENSMAMG00000008756.2.
DR GeneTree; ENSGT00940000157065; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00052; EH; 2.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11993; SH3_Intersectin1_4; 1.
DR CDD; cd11837; SH3_Intersectin_2; 1.
DR CDD; cd11840; SH3_Intersectin_5; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032140; INTAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16617; INTAP; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 20..106
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 53..88
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 219..296
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 252..287
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 687..758
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 823..882
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 909..967
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 983..1047
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1065..1124
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1147..1333
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 582..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 316..463
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 506..557
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 606..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1399 AA; 158152 MW; FDFA69C8046F2166 CRC64;
QVQSELPFAS PDVFLISMEE RAKHDQQFHS LSPTAGGYIT GDQAKNFFLQ SGLPPPILAQ
IWALADMNSD GRMDIHEFSI AMKLIKLKLQ GHPLPPTLPP SMKQPPLPLP PQPSFGMPPI
APIPASLPGV PPIPLPPLPV GVSPPLVSSG PPPLPQPIAN GAPPTGMMQP ISGFSHQGNI
TLPSSPALWE KSHHCIGFLF SVICPSSQPP SDWAVPQSSR LKYRQLFNSH DKMMSGHLTG
PQARTILMQS SLPQSQLATI WSLSDIDQDG KLTAEEFILA MHLIDMAMSG LPLPPPLYVL
NFKKILSIVT FEDKKRENFE RGNLELEKRR QALQEQQRKE QERLAALERE EQERKERERL
EQERRRQQEL ERQLEKQREL ERQREEERRK EIERREAAKR ELERQRQLEW ERQRRQELLT
QRNREQESIV LLKARKKTLE FELEALNDKK TQLEGKLKDV RFRLSAQRRE VEQTNQTRET
RIAEITLLQH QLQESQQWLG KLIPDKQSLS DQLKQVQQNS DSLSSLQKAV EQKETSRQQL
REQLDAVERE TRAKLLEIDA FNTQISFPSH RLSSEEGVAW RNEAGSSAPK APSPASASAP
HAWLNRVTQE EEERKRRGME EQEEARKGAA LVEEKEDEGK GKKDMQAKLN KLFSQPADPW
ALAVEKTPGP SLFDQKVSAS SFEQQPVKVV YYRALYPFDA RSHDEISITP GDVIMVRNTH
TKYPSVDESQ TGEPGWLGGE LRGRTGWFPA NYAERIPDTP GHTSSTSSAN NSEGWDAWPT
SSTTQNPSLS VPSAQLRQRS AFTPATMTTG SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN
HLNFNKNEII TVLEQQDMWW LGELQTGQRG WFPKSYVKLI SATMTTPSGV SDSPPNGKRP
SPSPTKPSES GEEYVAMYTY ESSEQGDLSF QQGDIVMVTR KEGDWWTGMV GSKTGVFPSN
YVKLRDSASD SLGPAGKTGS LGKKPEIAQV IAPYSATGAE QLTLAPGQLI LIRKKNPGGW
WEGELQARGK KRQIGWFPAN YVKLLSPSTS KTTPTEPTPP KLAPATLCQV IGMYDYVAQN
DDELAFQKGQ VITVLNKDDC DWWKGELNGR EGLFPSNYVK LTTDTDPSTQ WCADLHLLDM
LSPMERKRQG YIHELIVTEE NYVNDLQLVT EIFHKPLLEC ELLTEKEVAM IFVNWKELIM
CNIKLLKALR VRKKMSGDRM PVKMIGDILT NQLPHMQPYI RFCSCQLNGA TLIQQKTDDN
PEIKDFLKRL AMDPRCKGMP LSSFLLKPMQ RVTRYPLIIK NILENTPESH PDNSHLKAAL
EKAEELCSQV NEGVREKENS DRLEWIQAHV QCEGLSEQLV FNSVTNCLGP RKFLHSGKLF
KAKSSKELYG FLFNDFLCF
//
