ID A0A3Q3LK50_9TELE Unreviewed; 600 AA.
AC A0A3Q3LK50;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=ADP-ribosylation factor-binding protein GGA3-like {ECO:0000313|Ensembl:ENSMAMP00000009739.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000009739.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000009739.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR AlphaFoldDB; A0A3Q3LK50; -.
DR STRING; 205130.ENSMAMP00000009739; -.
DR Ensembl; ENSMAMT00000009990.2; ENSMAMP00000009739.1; ENSMAMG00000006574.2.
DR GeneTree; ENSGT00940000159613; -.
DR InParanoid; A0A3Q3LK50; -.
DR OrthoDB; 2917368at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF6; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 17..147
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 171..298
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 471..592
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 299..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 67352 MW; 5C9D31D402C4260A CRC64;
MASGDSPATF ESWLKEATDP NNQGDRWDCI QGFYQLVNQE SEGPQVALRL LAHKIQSPQE
KEALQALTVL EACMNNCGKR FHSEATKFRF LNELIKILTP KYFGAWTPQK VKDRVTEVLY
GWTLWLKEEP KIQEAYSMLK KQGIVKKDPK LPETLIMAPP PQRTTDSIFD QEDKDKLLAR
LLKSARPEDL EMANRIIKNT IKEEQEKEEK VLKRESTLKE VESSTKQLRE LLGQNTVSET
SLQTSDDVKA LYERCDRLRP TLFRLASDTM DDDVALAQIL AANDELTVAV NAYKEQVGRM
QCNGRRERSR SEEDALGKNN APTSPREIKS YHLIDLSALD SPQTQRKSDS PLSFQSSSPL
VSSHLESTFH SVADQDFNEL ELENQDSKQH QETQKSYYEE LMQLKGLEVE PNGGIGLLLT
ARGCTMSNGM NTWSISQNQL GSESVAQKQP NEMFGDTLRS IFVPMETIKS SQLEPIVLHD
QCGIHVSLHF AKDSAPGHPG VAVVVISTVN TSALEVKDFL FQAAVPKTML VKLQPASGTH
LPPYNPLLAP PAISQVLLLT NPQKCKVRVR YKLTLTHGDQ QLNKTGDINS FPDWTALVGH
//
