ID A0A3Q3LLJ6_9TELE Unreviewed; 4157 AA.
AC A0A3Q3LLJ6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dynein cytoplasmic 2 heavy chain 1 {ECO:0000313|Ensembl:ENSMAMP00000010214.1};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000010214.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000010214.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 205130.ENSMAMP00000010214; -.
DR Ensembl; ENSMAMT00000010474.2; ENSMAMP00000010214.1; ENSMAMG00000006729.2.
DR GeneTree; ENSGT00940000154620; -.
DR InParanoid; A0A3Q3LLJ6; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT DOMAIN 1674..1820
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1961..2116
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2273..2421
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 857..884
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2869..2910
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3085..3154
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4157 AA; 472927 MW; 29D4E6E7E225FDF4 CRC64;
MPDGSDDVRK KFILTTTGNF YGIKPPLSWA DSPELNNFLD DGNEFVLSIS GNDNNLHFSN
KIETSGDSKE KVLVFFKLHP TVITEENLHQ SLLVSSMLES PINTLYQAVR QVFAPVLLKD
ERWRSAFDPK LADLLSELEV GLGSVLRKSG AQPSAKKGRM EEDVLGILTP SDEFQYWADL
SESADKNRVR ERAAYFTEQF KPIQKEYDGL DGLSMSDVVD LVEQTKDTLD DVWRQTDFEP
YPETRMARLM DVIGGDLGRC VQRKLSGLKI FEESFISIRD NLRMSIAICE QWVVACEHLT
GQVWKRYAPH PWKGNKHCPQ ILHCLATRLD EVVTLRMVHE KLLRLLSGGK QQALTADRVF
EPFSGLNPLH YNPYTEPLWR AAVAQFERLM APSEQDVAGR LKSCIADVQD NPQQLLQVFQ
KHKELIKRPI ISKELQSERE TLLARLLDYN KGLKADFESR CHGGPGDKYG PLIGRNLPEV
VNKIVWVRQL IHKVEDSVRI TEALLPDLSG FKGFLHFCDN LLEFLRAYEQ EQFEDWSRDI
LSGLANPTSG ISNRVMDLDH VDGRLKIQYS DRLVSLLREV RQLSALGFPI PAKIQQAANT
AEKFYRQAII LKQVAHFYNT IDQQMIPSQR PMMLSLALAF EQVIKSNESC GKLQITWDNP
KELEVYIAKL QSVAEKLSTE NRKLRKWHTD FIDKVVTLMN VDLLRHQQRW KDGLQDLRTG
FATLEAQGFR SDDMRAWRQH WNHQLYKALE HQYQMGLEAL NKNLPEIHVD LTFKQGRLQF
RPPFEEVRAR YFREMRRFIS IPNQFKGVSA QGEELIFGIM IDRNASGFLT IFSKAEDLFS
RLQAIQHKFK EWVVLGQMDL EKLVEKHLNT VQDWERNFKA LKARGKESER LPSQEKIDCI
TVNCEPVKAV IEDLIQKLFD ILLSSLRKSI QGHTQAIDSF VSESMEALSI RPESMEEIAV
TTGKYSQILA HKPETLVQFQ CAEEKTRLLR AVAGAGLDSL SALRAKWDKL ELVMESHQLM
IKEQMEIMRS NAAGRINAYR ADLERFKARW DQLKPKDEVF DTSDDAALVV CLQTIRDKQQ
EFQELELVRS KLLEDCTYFD LEVPDFSLAE ETKRDMEEYS QMWGLYEDWQ KGFTEKAQED
WIIFRSKTYV FEEFLFTWQD RLRKLEQPTS MSVKLQGEVD KYKNMVPLLK YVRGEHLSQD
HWLDMFRLLG LPRGTTLERL TFNDLLSVAN TIIEKALELK DLNSRAQAEV TIREALRELD
LWGATATFNL TEYTDSSKRT LILIKDWKDI VNQVGDNRCL LQSLKDSPYY RSFQDKVSLW
EVRLSDLDEY LLNLNAIQRR WVYLEPIFGR GALPREEARF KRVDDDFRSI MSDIQRDNRV
VSLSSRAGIR NSLVTILDQL QRCQKSLNEF LEEKRSAFPR FYFIGDDDLL EILGQSTNPT
VIQSHLKKLF AGIHGVVFDE QCQHIVAMCS LEGEIVPLRN LIRISSLVEV WLSELSVEMK
ETLKHLLYEC VSAGRKGEVD PLGFPSQILC LAEQIQFTED VERALKEQNL QQLELELTAK
LEHYTTVDTS SDDNTNTESS ILQLKLKALI LDIIHNISVV KELNQAGVNS PDAWGWKKQL
RFYMGPDKCC YIQMVDAQFS YTYEYQGNAA KLVHTPLTDK CYLTLTQAMK MGLGGNPYGP
AGTGKTESVK ALGGLFGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF DEFNRLEEAV
LSAVSMQIQA IQDSLKHHKQ TCELLGREVE LDSNSGVFIT LNPAGKGYGG RQKLPDNLKQ
LFRPVAMSRP DNELIAEVIL YSEGFKNGEI LGRKLVAIFN LARELLTPQQ HYDWGLRALK
TVLKACGSLL HLQRRSHDKD KIQESSLVVQ ALRLNTMSKL TFTDSSRFDA LVRDVFSGVN
FTDVEDQILM HALEQVYKEA RLELIPSQLK KALELNEQLR QRMGVVIVGP SGAGKSTLWR
MLRAALSKTG KVVKQYTMNP KAMPRQQLLG HIDMDTREWA DGVLTHSARN VVKEPQEVNS
WIVCDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPSV NFLFETHDLS CASPATISRM
GMIFLSDEDI DVGALVKSWL RGQPEECRSN LENWMGDYFQ QALGWVLKQN DFVIETSLVG
TVFSGLSHLN AVTERGQFIV GLLRGFGGNL NFKTRQEFAK ELLSWARESP PDTKKPLDTY
YDSESGHLAA YKFQRPEGLT LEQLSHTHTL PVIETPDMQR GLHCFSPWLI AQHRQPFMVV
GPEGCGKGML LRYAFSRLRS TQVAVVHCSA QTSSRHVLQK LSQTCLLLNA NTGRVFRPKD
CENLVLYLKD INLPKPDKWG TSNLTAFLQQ VLTYNGFYDE NLEWVSLENI QVVASMSTVG
TICSHSLTSR FSSIVRICTI DYPDREQLQT IYSAYLHPVL LHSLGSQASW ASTGKTHQLA
GSLVHVYEQV KAKFTVDDHS HYLFTPCILT EWVLSLLRYD LTAAQSNVTD SVLEVVAYEA
RRLFRDRLVS SKDLHTFDNI LSSIIRGDWG SDALDNMTDG FYVTWGASEG AVMAPGQSLP
SHGKQLGCLN FADLKQVIQK GVVLYSRDNK ELDLLLFWEV CDFVSRVDRV LSRPGGSLLL
AGRSGVGRHT ATCLVSHMHG YTLFTPKISR GYTLKHFNND LKTVMQLAGL EGQQVVLLLE
DYQFVHPAFL EMVNSLLSSG EVPGLYTPEE LEPLLSSLKD AASQHGFTGP LYNYFSYRIQ
QNLHIVLIMD CSNSNFTINC ESNPAFYRKC SVQWMEGWSE SSMKKVRPNI RTKMDIKSVI
GDLCHLFRMV HESCREHGAT PNQYMAFLHV YTSIFSRKQS QLTTRQQHLQ AGVSKLNEAK
ALVDELKRRA AEQSALLKTK QQEADSALQE ITTSMQDASD QKTEMEKIKG KMAQEVSKIE
ERKAKIDDEL KEVQPLVDEA KRAVGNIKPE ALSEIRSLRM PPDVIRDILE GVLRLMGIFD
TSWVSMKSFL AKRGVREDIA TFEARNITPD IRQSVEELLN RNKASFDPKN AKRASAAAAP
LAAWVKANVQ YSHVLERIEP LEREQAGLLE NLRKTESRKN KLEDQLNSVG AKVKELKEKF
QCHTAEAAKL EAEVTKAQDT ITAAQQLISQ LDSEHTRWNT QVMSEIKNEL DTLPVRAMLA
AAFITYLSAA PEDRRRHCLE TWMAQSGLQK FDLRSFLCSE SEQLIWKSQG LPSDDLSIEN
ALVILQSVAC PFLIDPSSRA TEWLCTHLKQ HRLEVINQQD SNFMTSLELA VRFGKTLIIQ
EMDGVEPVLY PLLRRDLIAQ GPRYVVQIGD KVIDYNEDFR LFLATRNPTP FIPPDAASVV
TEVNFTTTRA GLRGQLLALT IQQEKPELET EKTRLLQQEE DKKIQLAQLE ESLLETLATA
QGNILENREL IDSLNQTKAS SALIQESLLE SHRLQASLDQ ERDAYLPLAE TASKMYFVIT
DLSKINNMYR FSLASFLRLF QRALQAKKET ENTEARILAL EASLKNMVYE YVCRSLFKAD
QLMFAMHFVK GMYPELFQEN EWDVFTGSIV GEVFKKEVRE FPSWIDQERH GAVAIFKATF
PAVYQSLCLS DSDLWLSFSQ SSQCEQEIPS TIAKKITPFQ QLLLVQAVRP DRLQSTMAAF
ASQALGKWFM LASHFLVVMK FFFGYFGCDI AFDCLFVGGT LARAQSLFCL AWFHAVCQER
RNYIPQGWTK FYEFSLSDLR AGFEIIDRLF EGGKSFQWEF VHGLLENAIY GGRIDNPSDL
RILRSYLEQF FSARLFSSSL SAGQRKGRGG TRFFPPQISL PNSCSILDYR SVIENLPEDD
RPAFFGLPAN IERSSQRIIS SQVISQLRVL SRSVATGSKF DRELWSNGLS PVLNLWKKLN
QGSTLIHQKV APPTEGHGSP VLSFITLEQF NAIRLVQSIH QSLAALSKVI RGTQLLTNEV
QKLATALLHQ ECPLTWQNKW EGPEEPMQYL RAVVSRTLAI QSWVERAGRQ ALLSDTLDLA
ELFHPDTFLN ALRQETARSM GCSMDNLVFV SSWRGPIAHA KLQVKVGGLQ LEGCSFDGVH
LCENQHDSPS VSVVPTCYMA WVPQVSAIYS PENTESIWLP LYTSSDRVKV VTHICLPCGA
NSSQWIQTGA ALFLKQQ
//
