ID A0A3Q3LLL1_9TELE Unreviewed; 4273 AA.
AC A0A3Q3LLL1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=FAT atypical cadherin 2 {ECO:0000313|Ensembl:ENSMAMP00000015058.2};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000015058.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000015058.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMAMT00000015477.2; ENSMAMP00000015058.2; ENSMAMG00000010137.2.
DR GeneTree; ENSGT00940000158507; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 30.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF445; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 28.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 31.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00232; CADHERIN_1; 13.
DR PROSITE; PS50268; CADHERIN_2; 31.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..4273
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030081179"
FT TRANSMEM 3976..3996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..146
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 147..254
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 358..453
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 454..559
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 566..681
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 703..807
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 808..912
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 913..1019
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1020..1124
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1125..1277
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1304..1369
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1370..1475
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1476..1580
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1581..1678
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1679..1792
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1793..1888
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1889..1990
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1991..2091
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2092..2192
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2193..2299
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2300..2401
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2402..2505
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2506..2612
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2613..2718
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2719..2830
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2831..2936
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2937..3038
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3039..3143
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3144..3247
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3248..3352
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3353..3457
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3679..3860
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3862..3899
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4227..4273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4244..4261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3889..3898
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4273 AA; 471618 MW; F8EA80DAB5F529C6 CRC64;
LVLLTLAAVL LHMVRCQGSV VKGKNSSPLR FTHHLYNVTI NENSAPRTYV ETPVKMGVEV
THLLWEIKYS VVSGDDDGLF QAEAVQVGDF CFLRIKTRSS NSALLNREVR DTYTLTVEAT
ESTFDFHAKT KVLVLVLDTN DLKPLFYPAS YNVAIREDSP LKSSVVRVSA TDADMGSNAE
FYYSFTSRAH PFVVDPFTGT VSLVKKLNHT RSERYDLTVL AEDRTKKISG VQKFGNVAKV
TVNIQKMSLG PPVIIPPPRP TVSEDGKVTV KVHVEAGVKP VESLYIIEGD PHKCFEIIPL
GVQGSDFQVI STKRIMWSQS PFGLNLSLQA KDRSFPSLLS PVTQIHIPAH HYSRLAFLED
TYIVTLSEFS PPKTHVVKVS VTSVPYNVTF SIKTNPDSSN FRINPKTGII ITTEKFDYER
KDRYEFDVMA NHGEAETHIV VEIIDENDNS PQFTHTSYQD TLDENTPVGS SVLKVEATDA
DKGKNGFVTY AIANSGPLPF TIDPFTGVIS TSEYLDYELM KRRYHLTVWA SDSGSPFSRV
SECSVTITLN NINDNIPLLE RVDCNATVPL DLPVGNTIAE LSAIDLDELQ QLRYMIQSGN
DLQVFGIDSV SGAVTLKQPI PLRAGAFTLR VVAIDGKHHS ETSVVRITVT NRGDNATLHC
RETGIHKQIT DKLLESIKPV LTSQEETFSD IHITNRHSPK FDQSIPGSID LIENHPLIST
VVQFKATDND TGFNGKLVYA ISSGNEDSCF SIDTFTGDLH LVCPLDREIK EFYILNITVY
DLGTPQTSAW KFIAVNVIDV NDNAPVFDQS RYVIHVPENT EVDSIIFAAR AVDVDTDTNG
NVQYSLLTST DMFRIDELTG EVTVTGHLDR ETSPRHDLLI EARDQAKLSP QMFSTTDLVV
VLQDINDNPP KSVPNVYKIK VPEDVPVGTL LVWVESVDLD LGSGGLVTYN LKNTESGIFQ
LDSSTGALTL ERELDFERQP FYNLTVRAVD HGLPRSLSSS CFVEIQVLDV NENLHRPVFT
EFVYEAGVME DSAVGTSVVM LTASDKDLGR DGVVRYHIHD GSGLGVFTVD EETGVIRTTQ
MLDRETMPHY WLCVYVTDLG TEPLISWTHV YLEVLDVNDN APELSQPVYF VSVQENMDKV
KSVVQVSAKD LDTSSEGKLS FQMLESHRTY FDVDPKTASQ HMQREVCRMV ACDDDEGSNA
AVTYSLQDNR DEHFQIDTVT GVVTSHGDFW PGNYSILTIR ATDQGSPSRS STARLDIEWI
ARPPPSTEPI TFEEPHFTFA VMETEPVTHM VGIIMTETHR LRWFDIIGGD EEKDFDIQRN
TGTISIARRL DAARRSNYNL TVQVTDGHQY ATTQAYIRVL DMNEHRPVFT KPLYEVRVPE
DTSPWKDILQ ISARDADTNS KLVYSIHSSL HPNSTKFFHL DPKSGVLVMT EELDYEMISV
HTLIVMVRDQ EIPVKRNFVK VVVHVEDCND HSPLFLTPRY EASISSLASP GSEVIQVKAL
DKDVGSNAEI SYSLHSGNIN NIFSIDAELG SIRVSKPLDL QPQDQFHLTV KATDQGFPQR
SDLCSVHINI RISDQTPPAF LSDEYITEIS ELSALGTPVV TIAASSPAAV HYGIESGNLN
GTFLINPYTG LISTQKHLDF ENCVSYKLKV TASTAAGATS KTIVFIYVID ENDNAPVFQH
KEYLGQISES AHINSMVMGE RNVPLVIKAS DEDRDANALL VYQILDPEAL EVFKIDSSMG
TISLISPVDF EAKPVYRFTV QVKDSGEPSL FAAEPATVTV RILDLNDCPP QFTSPVYEAS
LIFPVVRDTE VVRVMANDAD SAVSYSITEG NLHNAFSIHP STGVITVSTV SEFGHFHQLV
VKASDGLYKD SATVRVNVTN LTASNLGFEQ KVYSASVTEN LKYVKTLAAL KATGCYLNEP
LVYSVVNPMG RFAISQTSGV LETTGVPFDR EEQDIYDVVV KVQDMRTPPR TATTQVKVFI
DDVNDNAPQF LNLPFSMMIS EDSEPGDVLY QATAMDRDLG ENGSILYSLE DDYNLFRIDP
DVGDVSLRSP LDFEALNKYV LTVLAVDEGE PSHSTIAELS IQVRNRTNPV FQTLLYPLKV
PENVPPFTTI LHVQARNPEG YRLIYNLEEE NASKHFNIDF KTGVLTVTNP LDYESEAMHV
LTVRATDSVT GAFSEASIEI EVEDVNDNAP VFSKLMYSVN IAEGLPVGTS VIQLSASDRD
SDRNKDLTFS IVRTDLDETD FFEIDPHSGL IATKQVLDYE HTKHFKLKVK ASDNGTVPLS
SEAYVIINIT DVNDNPPDFV SSQYETSLDE MAKCGHIVIK IQASDPDTGD QNDLKYKILS
GNEGRYFNIN ESSGIISFSN VCKRNLDPYY NLTVAVSDGV FQKTAPVTID MIKSNRHAPY
FKQSIYEAEL AENAEAGTRV IRLAAIDPDE GPYGSVDYTI INKLADEKFA IDHDGQIITT
QPLDRENPAQ RVIAIKVMAK DGGGKVAFCT VKIILTDEND NVPQFKASEY QVSIQSTVNK
GSPVIQIMAY DADDGKNADV TYTVDEAAEV TEDIIEINPF TGVVSVKESL VGMENKIFNF
KVKARDGSLP FYNSTVPVQV KVVPPEVPLP KFSEPLYTFS AAEDIPIGTE IGSVRADSDM
PLIYSLVNGN TVESNRDKVF SLDKESGTLL LQKTIDHEKT KWYQIDVIAQ GNHNGTDVAS
LVSVSIQVQD VNDNQPVFDA SPYRAFLAEN MPAGTTVIQV TANDPDTDGN GLVTYTLESL
PGGSTADITE VFSIDGESGW ITTVRETDCE VTRVYRFNVV ATDHGGDAKL SSSVLVEVTV
TDENDNPPKF SDDVYRGSVL EDSVSGEVII SMTTTDVDVS LENRLVTCYI TDGDPLGQFA
IIQEDEGQWG LIVKEQLDRE TKDRYRLKVV ATDGKFEAPV TVDVHVLDIN DNSPLCEQLV
YTEVVMENSP SSMFVLKVSA SDPDVGANGQ ISYSLHGPDA DKFHLDPRTG ELFTLAVLDR
EREVEHNLVA KAADGGGRSC QADILLMVQD MNDNAPVFSS SHYEVTVFDN TTVRTPITII
YAKDPDTGIN SEVKYSLLED EGGYFSLDEF SGILRLERPL TPDAPERFNL KVKATDRGLP
RHLYSVATVT VDVVSLNDYR PIFLSSEYTV QLPESLAVGT EVLNFEHHIR DYADLFQVAF
VIVSGNEDGP FQLHHLAGVL TLDAPLDYEV SQVYYLTVEG RRTLSSLSDI TTIIINVTDV
NDNSPVFGQG DYRAEISEDL LPGSLVMKVT ATDEDGPVNN LLRYSIVSGD PLQQFSIHPR
SGEITVRTAL DREEIPHYSL TVQAADEGNP PLSSAALITI TVADVNDNPP VFSEVNRSLL
LQEGESVGSS ILQLVVTDKD TPRNGPPFSF HIVSGNEDRR FHVDQGGLLS LSAPLRKKVK
PQHQLKIQVT DSGHPPLSSI CVVNINVTEQ SKYPPSVVPL EVFITTSGGL FANRVIGKLH
ASDQDLQDVL TYKLVSENPD GGRFSVDMAD GKIWADENLQ DGSYSLNVSV TDGKFSVWTG
VKVHVWVPDQ RALDSGLTLQ LVGISPEEFL GDHWRGLQRS LGQALGLPRQ ELHLVSLQEQ
RDAQVVELLD AGIISDIEDS LGLRILRMSH DGCLGTGCPP RGCRNAVRLM GERLSHFSTA
RAGYITPQHT WESVCPCNES AVKFDGKSYL KYLHRMDEDN QDFKLSLRFR TFQSQGLIVS
TNSTKDWGAL QVFTGGELQL RYSCGNTSPG SLLLTSHPVS DGKWHTVLLE VNTTALRLTL
DQRPPVSAAL TEPCRMMRSH GALLFAAVPQ DSAPEGARNL HNFTGCMEGL ELNGEPIAVG
DTAEWSRPGS RRVFGVYRCC SRVGACDNNP CLNSGVCEEE AAGEPRCRCT GLFHGARCEL
ADNPCASQPC AQGRVCVPKA QGYICNSPSI QPGCHNLVED CLPNSCPGGY DCKVTNGSIH
CDPMPQVIPM IGSVEIMEIC GSVLGLLFLV GVFVCIRKRY IQQKKKKPAC VQDSNGYFQP
SQAKGLKAHN HEVNPIEMSS LVSPTTDIDH TPFRSLRPRS QISLSGGSAS SPKTQGPVVC
SVAPNLPVRP PSSSDTDSIR KNQWDMDYEV YPADPDYYGR PTVREFPQFD IVEDTYSTST
MDSRRNSRFG GFPFPLDRCD RRAPLPPCYS NQNLDDFLGP DGLPLPSSQC PNEYTAISYY
PTHHTHSLEN VSGYKRLSMR LSVAMPSYAE QASPPPAPNP AQPQTRPAGR NTRSYDGSSM
VESDYGSCEE VMF
//
