ID A0A3Q3LQ50_9TELE Unreviewed; 511 AA.
AC A0A3Q3LQ50;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Early growth response protein {ECO:0000256|RuleBase:RU363046};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000012206.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000012206.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcriptional regulator. Recognizes and binds to the DNA
CC sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target
CC genes. Binds double-stranded target DNA, irrespective of the cytosine
CC methylation status. Regulates the transcription of numerous target
CC genes, and thereby plays an important role in regulating the response
CC to growth factors, DNA damage, and ischemia. Plays a role in the
CC regulation of cell survival, proliferation and cell death.
CC {ECO:0000256|RuleBase:RU363046}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU363046}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682, ECO:0000256|RuleBase:RU363046}.
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DR AlphaFoldDB; A0A3Q3LQ50; -.
DR STRING; 205130.ENSMAMP00000012206; -.
DR Ensembl; ENSMAMT00000012531.2; ENSMAMP00000012206.1; ENSMAMG00000008272.2.
DR GeneTree; ENSGT00940000165075; -.
DR InParanoid; A0A3Q3LQ50; -.
DR OrthoDB; 2912670at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR021839; EGR1_C.
DR InterPro; IPR021849; EGR_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF42; EARLY GROWTH RESPONSE PROTEIN 1; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF11914; DUF3432; 1.
DR Pfam; PF11928; DUF3446; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU363046};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU363046};
KW Metal-binding {ECO:0000256|RuleBase:RU363046};
KW Nucleus {ECO:0000256|RuleBase:RU363046};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|RuleBase:RU363046};
KW Transcription regulation {ECO:0000256|RuleBase:RU363046};
KW Zinc {ECO:0000256|RuleBase:RU363046};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042,
KW ECO:0000256|RuleBase:RU363046}.
FT DOMAIN 313..342
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 343..370
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 371..398
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 137..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 54970 MW; 42FDE12F37C95A19 CRC64;
MAAAKTEMIL PALPISEPLS FPHSPMDNYP KLEEVMMLSS AGTPFLTASA PEGAGFGSGE
PGEQYDHLAG DTLPDIPFNC EKSVAEQTYP TQRLPPISYT GRFTLEPATT CSNSLWAEPI
LGLFTGLMNN VAASSSSSSA ASQTSSSSSS SVPSSTTSSS STSSSQSSSL SSSIHHSEPN
PIYSAAPTYS SPNSDIFPDQ GQAFPSSTGA VQYPPPAYPN SKSCSTSFPV PMIPDYLFPQ
QQGEISLVPP DQKPFQSQSS QPSLTPLSTI KAFATQTGSH DLKNAYQSQL IKPSRMRKYP
TRPSKTPPHE RPYACPMETC DRRFSRSDEL TRHIRIHTGQ KPFQCRICMR NFSRSDHLTT
HIRTHTGEKP FACEICGRKF ARSDERKRHT KIHLRQKDKK AEKAGAVVVT AAPVSAASPA
SSYPSPITSY PSPVSSYPSP VTSCYSSPVH TSYPSPSIAT TYPSASMSST FQSQVASSFP
SSVASNIYSS PVPTPLSDMQ TTLSPRTIEI C
//
