ID A0A3Q3LQJ1_9TELE Unreviewed; 706 AA.
AC A0A3Q3LQJ1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase {ECO:0000256|ARBA:ARBA00026102};
DE EC=3.6.1.62 {ECO:0000256|ARBA:ARBA00026102};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000015492.1, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000015492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside
CC in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) +
CC N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692,
CC Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461;
CC EC=3.6.1.62; Evidence={ECO:0000256|ARBA:ARBA00024496};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485;
CC Evidence={ECO:0000256|ARBA:ARBA00024496};
CC -!- SIMILARITY: Belongs to the DCP1 family.
CC {ECO:0000256|ARBA:ARBA00008778}.
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DR AlphaFoldDB; A0A3Q3LQJ1; -.
DR Ensembl; ENSMAMT00000015921.2; ENSMAMP00000015492.1; ENSMAMG00000010519.2.
DR GeneTree; ENSGT00940000158409; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd09804; Dcp1; 1.
DR Gene3D; 6.10.140.2030; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010334; Dcp1.
DR InterPro; IPR031953; mRNA_decap_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16290:SF5; MRNA-DECAPPING ENZYME 1B; 1.
DR PANTHER; PTHR16290; TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1; 1.
DR Pfam; PF06058; DCP1; 1.
DR Pfam; PF16741; mRNA_decap_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 3: Inferred from homology;
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640}.
FT DOMAIN 664..703
FT /note="mRNA-decapping enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16741"
FT REGION 181..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..465
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 75632 MW; 062A17ED02A8737E CRC64;
MTATSSGSSS CLAAKGLDIS LAALQRQDPY INTIVDVASQ VALYTYNNRA NEWEKTEVEG
TLFIYTRLAS PRHGFTIMNR LNMENLTEPI TKDLDFQLQD PFLLYRNARL IIHGIWFYDK
EDCQRIAQRM KILTQQEQVL AQSQAGWLSP GRGGVGGVGG VGGVGGVGGV GGVGGVGGVG
GSGTGTRTGT GSGIGSGTRS GGGGVVVGGG ESEGKGVDII QMLTKARTEY DKEKSTSEPK
EIGGSSVLYG NPNLIKPIPV KPNTQDSEGA EPKSLSLATL FGAQLQHHHS SKPDPISPVA
GIGSSAGKAA RPPVARTLTY DDTVNSGESV TSKGGNVTLA GCSDAEIRAG GPGVTGLLQS
PITAHPQQNQ QHHCPAIQKL MQGQRGVSGV LQTVSESPEN RLCDNGMPLE HHHLYHHHQQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QHHRHHHHHH HHHQQQQQQP QSDPIKRLFQ
TQPPPLTSAP ISSAAPPCSN PLHLQPEPCL SSQPTQPEAQ HNSQSALTAQ GSGLPSHMPG
VVSPHELLQK LQLVQQEQNL ALHDPPQLCP GLAPRFVGST QNQNAGSLVG PVPNQTPGAA
GQKAALQFQV ISPQRIPATV APTLLLSPSV FTHTKSSSGW SVVAQDSIPG PSNMSRPLLQ
DKLKVLSKSQ FQATLLHLIQ TDNSFLDNIY EAYVSRFASD TSSSEY
//
