ID   A0A3Q3LRP5_9TELE        Unreviewed;       973 AA.
AC   A0A3Q3LRP5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Alpha-2-macroglobulin-like 1 {ECO:0008006|Google:ProtNLM};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000012029.2, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000012029.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR   AlphaFoldDB; A0A3Q3LRP5; -.
DR   STRING; 205130.ENSMAMP00000012029; -.
DR   Ensembl; ENSMAMT00000012352.2; ENSMAMP00000012029.2; ENSMAMG00000005575.2.
DR   GeneTree; ENSGT00940000162996; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd02897; A2M_2; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR041813; A2M_TED.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   PANTHER; PTHR11412:SF150; ZGC:171445 PROTEIN-RELATED; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          189..321
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          425..514
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   973 AA;  107743 MW;  14B0A01DAB92205C CRC64;
     VLEAGAQARF CASLLQPSET LVMTVSLVSG QKSITLLKKT SSRAFHDCTQ FKVSSRVRLL
     FTWLFPKTFP MTFVQTDKPL YLPGQTGNLR LIFNDVITPN PYDIIEIEDA SGNRIGQWLN
     ETSTRKIVQL SYTLSSEARE GIYQIIVTIG EDKVYHTDEV SVAQEYTFGQ PVPGSVKVEM
     CRPSQPYFAN IRLAKPAFPP GVPDVTPPCS KETKQVNFDI FTWVSYSWFI VPVTQGQVSF
     KLNVSPEMVP LVQVVAYAVL PSETVIASSA DFSTEKCFTH KVSLEFTPSS AVPGEQVTMT
     LTAEPHSLCG VSAVDRSVFI KEPGKSLDIF SLLPVVTGSY IPYEVQDSTE CFNVRAKRSR
     FFPYPGPDAS DDAFTVFQNV GLKMVTNLLI QIPSCLRFKG REYQQGAVTY RLFTIVTVRT
     FFPETWIWEL VDVGLCGIVD IPLTVPDTIT TWETEVFCLS LVGFGLAPRT TLTVFQPFFL
     ELTLPYSVIR GERFELKATT FSYLTSCIMV TVTPAPSLDY TLTPLSGGQY TFCLCGSERK
     TVSWTMTPST LGTVTVSVTA GAVASQASCG NEIVSVPERG RIDVVTKSLI VKAEGIKVIK
     TYNWLLCPKE TLTEELQIQL PTDVIPGSVR VLVSVLGDIL GRALKNLDGL LKMPSGCGEQ
     NAAALASDIY ILEYLTVTQQ LTQAIKEKAT TFLISGYQRQ LNYKHADGAY SAFLTVAGNT
     WLTAFVVRCF TKAQSFIYID PQKIEESKTW LLQQQRQTGC FVMSGELFHN DMKGGVSDEV
     TLSAYITAVF LEMKMPVSDP VMNKSLSCLK QSVSNLNNTY TTALLAYVFT LAGDMETRAQ
     LLQHLDTVAI RQGGFLYWSQ TSTETSASLS VEISSYVLLA KLSASPTDED LGYASFIVRW
     LTSQQNHYGG FSSTQTLYPC HSFLLYSDFS FSGLEINGFQ KGFWVKSYWI WELVDVGCVS
     VANGLACKYT LHV
//