ID A0A3Q3LRQ1_9TELE Unreviewed; 1885 AA.
AC A0A3Q3LRQ1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Plexin A4 {ECO:0000313|Ensembl:ENSMAMP00000015912.2};
OS Mastacembelus armatus (zig-zag eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000015912.2, ECO:0000313|Proteomes:UP000261640};
RN [1] {ECO:0000313|Ensembl:ENSMAMP00000015912.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 205130.ENSMAMP00000015912; -.
DR Ensembl; ENSMAMT00000016345.2; ENSMAMP00000015912.2; ENSMAMG00000010728.2.
DR GeneTree; ENSGT01050000244850; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000261640; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF34; PLEXIN-A4; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1229..1251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..495
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1255..1282
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1885 AA; 211603 MW; 3A19DD12FE773643 CRC64;
GFDLAHSAGS QVITASIQQE EYASFRAENP EWTFNHLAVD YRNGNVYLGA VNRIYKLSPG
LEVQVSHETG PDEDNRKCYP PRIVQPCSEP LTLTNNVNKM LLMDYRENRL LACGSLYQGI
CKLLRLDDLF KLGEPFHKKE HYLSGVNESG SVFGVIVSYG NASPDMLFVA TAVDGKPEYF
PTISSRKLAR NSEEDGMFAY VFHDEFVASM IKIPSDTFTV IPDFDIYYIY GFASGTFVYF
LTLQPEMGGG PTTGSSSAGR EQVYTSKIVR LCKADTAFNS YVEVPIGCIS GNVEYRLLEA
AYLSKAGAIL ARSLDVAPDD DVLFAVFSKG QKRRPRQASQ DSALCVFSLR KINEKIKERL
QSCYKGEGTL DLAWLKVKDI PCSSALLTID DDFCGLDMNA PLGVSEMVRG KPLFSDAVDK
MTSVIGYVYK NHSLVFVGTK SGRVKKIRVD GSSRALQYET VQAVENGPIL RDMAFSSDHH
YLYVMSETQL SRVPVEACGQ YSTCSECLGS GDPHCGWCVL HNMCTRKEKC ERSSEPRRFA
SDIKQCVRLS VHPNNISVSQ FSVTLVLEAH NVPELSAGVN CTFEDLAEMN GLVEGNRIKC
SSPAEKEMPR IIVDKGDHQI VQLYLKSKET GLAFANTSFV FYNCSVHKSC LSCVSSPYQC
HWCKYRHDCT HDPRTCSFQE GRVKKPEGCP QLLPAERILV PVNVVKPITL RAKNLPQPQS
GQRGYECLLT IQGNEHRVPA LRFNSSSVQC QNTSYFYDGM EMSSLPVELT VIWNGDFSID
NPAHNKVHLY KCDAQRGSCG LCLKADPLFG CVWCKGENRC TLKQHCPHPE NQWLEHNGIN
SKCTHPRITQ ITPLRGPREG GTLVTIRGEN LGLEFREIQG NVKVAEVDCT PIREGYIPAE
QIVCEMGKAE KSQYTGNVQV CVGVGECRPE FMAKSSKYYY FVIPRIINLK PSRGPVSGGT
IVNITGSHLD AGSNVSIMFK DQPCTYLRRG GQWLTCRTYA SLHGYGNVSV SVSIDKAHLQ
KDLRFEYVED PTITKIEPEW SIYSGHTPVI VTGTNLDIIQ TPLIRAKYNG HETLNLCQVL
SPTSMLCQAP ELPISLARHQ EVPERPDEFG FKLDDVQALM ALNNTNFIYY PNPEFEPLSV
SGVLELKPGS PIILKGRNFL PPTNSGNGKL NYTVLIGEKP CVLTVSETQL LCESPNLTGR
HKVLARVGGI EFSPGVVHIT SDSPLSSTAI IGIAAAGALL ILFIVVVLIA YKRKSRESDL
TLKRLQMQMD NLESRVALEC KEAFAELQTD IHELTSDLDG AGIPFLDYRT YTMRVLFPGI
EEHPVLRDLE VPGYRQEQVE KGLKLFGQLI NNKVFLLCFI RTLEAQRGFS MRDRGNVASL
IMTVLQSKLE YATDVLKHLL SDLIDRNLES KNHPKLLLRR TESVAEKMLT NWFTFLLYKF
LKECAGEPLF SLFCAIKQQM EKGPIDSITG EARYSLSEDK LIRQQIDYKT LVVNCIHPEN
EKSPEIQVKV LNCDTISQVK EKILDAIYKN VPHSHRLKAS DMDLEWRQGR GQRMILQDED
VTTKIEGDWK RLNMLAHYQV PDNAVMALVP KQVTAYNSVN NSTVSRTSAS KYENMIKYTG
SPDSLRSRTP MITPDLESGV KVWHLVKNHE HGDQKEGDRG SKMVSEIYLT RLLATKGTLQ
KFVDDLFETI FSTAHRGSAL PLAIKYMFDF LDEQADKHNI HDPHVRHTWK SNCLPLRFWV
NVIKNPQFVF DIHKSSITDA CLSVVAQTFM DSCSTSEHRL GKDSPSNKLL YAKDIPSYKS
WVERYYSDIS KMPAISDQDM NAYLAEQSRM HMNEFNTMSS LSEIYSYVGK YTEEIVCSLE
QDDAARKQRL AFKLEQVVAF MSLES
//
