ID A0A3Q3LS83_9LABR Unreviewed; 1804 AA.
AC A0A3Q3LS83;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000011375.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000011375.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR STRING; 56723.ENSLBEP00000011375; -.
DR Ensembl; ENSLBET00000011965.1; ENSLBEP00000011375.1; ENSLBEG00000008227.1.
DR GeneTree; ENSGT00940000158289; -.
DR InParanoid; A0A3Q3LS83; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005450; VDCC_L_a1ssu.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF9; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR PRINTS; PR01634; LVDCCALPHA1S.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180, ECO:0000256|PIRSR:PIRSR602077-
KW 3}; Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 73..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 798..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 838..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1048..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1118..1139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1159..1177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1189..1206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1278..1300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1364..1387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1403..1438
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 737..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1616..1666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1765..1804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1621..1666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1780..1804
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 310
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 619
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1021
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1804 AA; 205194 MW; 004A9B3D141615BC CRC64;
MELVSGGGEK MAANAEAAKP VIMNEEELKR KQREKLKKLQ ATGGNPRPAR SLFLFNLKNP
FRKACINIVE WKTFEIIILL TIFANCVALA VFLPMPEEDS NQTNTNLESL EYIFLIIFTL
ECFLKIVAYG LVFHEGAYLR NCWNILDFVI VFMGLFTFAL DTINKIAGVP MEKGGGFDMK
ALRAFRVLRP LRLVSGVPSL QVVMNSILKA MLPLLHIALL VFLLVTIYAI MGLELFKCKM
HKTCYYSNTN IYATAELELP APCAQAGNGR RCSINGSECR PGWEGPNNGI THFDNIGFAM
LTVYQCITME GWTKVLYWVN DAIGNEWPWV YFVPLILVGS FFVLNLVLGV LSGEFTKERE
KARSRGEYQK LRERQQLDED LHGYMEWITY SEVLDADREG LLPLTSGDSD TDSLYDMEGK
SRIVYYYRLA RRWNRFFRMK CLVYVKTKSF YWLVMFLFHH QPESLTSLQD VASRLLLVLF
VVEMFVKMYA LGPRAYFMSL FNRFDFFVVL CGILEMIMFS AGAVAPLGFS VLRCIRLLRI
LKVTKYWTSL SNFVASLLNS VRSIASLLLL LFLFIVIFSL LGMQVFGGKF NFSDNRPRRS
NFDNFPQALI SVFQVLTGED WTSIMYNGIM AYGGPVFPGI LVAIYFIILF VCGNYILLNV
FLAIAVDNLA EAESLTSAQK EKAEEKMKRK ILRSKMPEKT DEERERLAKK LAEQRAKMEG
MPTTAKLKID EFESNVNEVK DPFPPDDFPG DDEEEEPEIP LSPRPRPMAD LQLKEEAVPL
PEASSFFIFG PQNKFRKLCY KIINASSFTN LILLFILLSS ISLAAEDPID PKSYRNQILA
YADIVFTTVF TIEIVLKMTV YGAFMHEGSF CRNSFNILDL IVVTVSLLSM GMESSAISVV
KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIKTIGNIVL VTMLLNFMFA CIGVQLFKGK
FYSCTDTSKM TAEECQGMFW KHMDNSLQDT VLAKREWINS DFNFDNVLYG MLALFTVSTF
EGWPKLLYRA IDSDQEDMGP VFNNRVDVSI FFIIYIILIA FFMMNIFVGF VIVTFQQQGE
QEYKNCELDK NQRQCVQYAL KARPLRCYIP KNPYQYRVWY IVTSCYFEYL MFFLIMLNTL
CLGMQHCNQS DHVTKLSDML NLIFTVLFTV EMILKLMAFK ARGYFGDPWN VFDFIIVIGS
VVDVILSEVD TALASSGGLY CLHGCAETNP MQAIAASENA SVSITFFRLF RVMRLVKLLN
RSEGIRNLLW TFIKSFQALP HVALLIVMLF FIYIFGKIAL VDGTQINRNN NFQTFPQAVL
MLFRCATGEA WQEVMMASMY GKKCDPKSDF LPGEEFTCGS NFAVFYLLSF YCLCAFLILN
LFVAVIMDNF DYLTRDWSLL GPHHLDEFKK IWAEYDPEAK GRIKHLDVVT LLRSLQPPLG
FGKFCPHRAA CKRLVGMNMP LNSDGTVTFN ATLFALVRTA LKIKTEGNFE QANEELRAII
KQIWKRTSMK LLDQVIPPIG DDEVTVGKFY STFLLQDHFR KFLKRQEEYY GYRPSKKSAT
GPEIQAGLRG LDEEVAPEMH RAISGDLQNE EEMERAMEES GEEGIYQRSH GLFGNRVDSF
SDEPANAQSQ QMTNQRPLMF SESQPESPPN SSALTPTTEF FPSTAPKNNT NNNAFADVWM
HLFCLQFPYD PNYGEGQSRS SRTAADQLVQ EALVKGGLSS LAEDPGFASV AKNEMAEAMH
TSLHDMESVA LGILAYVKKR RPIPVPPSAP AVAAKATGEP DPAVRRKRRP IPRIPAVHED
DTRV
//
