ID A0A3Q3LWG5_9LABR Unreviewed; 995 AA.
AC A0A3Q3LWG5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 12 member 5-like {ECO:0000313|Ensembl:ENSLBEP00000012750.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000012750.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000012750.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q3LWG5; -.
DR STRING; 56723.ENSLBEP00000012750; -.
DR Ensembl; ENSLBET00000013410.1; ENSLBEP00000012750.1; ENSLBEG00000009743.1.
DR GeneTree; ENSGT00940000165387; -.
DR InParanoid; A0A3Q3LWG5; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..275
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 391..674
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 689..806
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 821..960
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 15..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 109834 MW; 5422A1556B60509D CRC64;
LSRVWCFCVS GDGNPKESSP FINSSAASDA EKSQQYDGKN MALFEEEMDT SPMVSSLLSS
LANYSNLPTG SKEHEEAENN EEGARPSKKP VKVPQLGTLM GVYLPCIQNI FGVILFLRMT
WMVGIGGVLG SFIIVFMCCS TTMLTAISMS AIATNGVVPA GGSYYMISRS LGPEFGGAVG
ICFYLGTTFA GAMYILGCIE ILLIYIVPQA AIFKIEGLEG AEAEAALLNN MRVYGTIVLS
FMALVVFVGV KYVNKLALVF LACVILSILA VYAGVIKTAL DPPVFPVCLL GNRTILSKGY
DICAKVIEID NDTVTTKLWR TFCDSDSINA TCDDYFNTNN VTEIQGIPGV TSGILAENLF
GNYLEKGMFL EKRGLPSDAD PDSPPAGSNR YVLADITSFF TLLVGIYFPS VTGIMAGSNR
SGDLRDAQKS IPIGTIAAIT TTSIVYMSSV VLFGACIEGV VLRDKFGEGV NGNLVIGTLA
WPSPWVIVFG SFFSTCGAGL QSLTGAPRLL QAISRDGIIP FLRVFGHGKA NGEPTWALLL
TASICEIGII IASLDAVAPI LSMFFLMCYM FVNLACALQT LLRTPNWRPR FKFYHWALSF
LGMSLCLSLM FICSWYYAIV AMGIATCIYK YIEFCGAEKE WGDGIRGISL SAARFALMRL
EEGPPHTKNW RPQIMVLVSV DAEQNVEQPR LLSLTNQLKA GKGLTIVGTS VQGTFLDNYV
ESQRADQSLR KLMETEKVKG FSQVVISSNL RDGTSHLVQV GGLGGLKHNT VMVCWPKNWK
QPEYHQHFRN FIEVVRETTV ASMALLVPKN IHSYPSNGER FTEGHIDVWW IVHDGGMLML
LPFLLRQHKV WRKCKMRIFT VAQMDDNSIQ MKKDLIIFLY HLRIDAEVEV VEMHDSDVSA
YTYEKTLVME QRSQILKQMH LTKNEREREI QSITDSSRGS IRRKNQPGLR SQQSMEEASV
AEKPEDEVML HVPLRRNDQF IDFSLSPLCA LAWAK
//
