ID A0A3Q3LYW0_9LABR Unreviewed; 1456 AA.
AC A0A3Q3LYW0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4-like {ECO:0000313|Ensembl:ENSLBEP00000013670.1};
GN Name=HCN4 {ECO:0000313|Ensembl:ENSLBEP00000013670.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000013670.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000013670.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC {ECO:0000256|ARBA:ARBA00006305}.
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DR STRING; 56723.ENSLBEP00000013670; -.
DR Ensembl; ENSLBET00000014425.1; ENSLBEP00000013670.1; ENSLBEG00000010562.1.
DR GeneTree; ENSGT00940000154743; -.
DR InParanoid; A0A3Q3LYW0; -.
DR OrthoDB; 74296at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF4; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022566};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 239..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 571..686
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1304..1456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1210..1252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1440..1456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1456 AA; 154948 MW; 9F084CFB31ECDEF5 CRC64;
MDRLHSSMRK RLYSLPQHIG QKASVMGEGE DADKDTRRKS IRMKPLPSPS PTSGGSCKGI
GETKSGESGI METDIGRPMK TSSNGDCRRF RGSLSSITSR HVHDSDSAEE RRLITEGDVT
PSEESPPGTL GDGPPDQGAQ GGSGSGGGSG GGDGDGAQKE SPDQQPGFIK LDGIDQILPD
DERLYQAGFI HRQFGAMLQP GVNKFSLRMF GSEKAVEREQ ERVKSAGFWI IHPYSDFRFY
WDLTMLLLMV GNLIIIPVGI TFFKDEHTPP WIVFNVVSDT FFLMDLVLNF RTGIVKEDNT
EIILDPQQIK VKYLRSWFVV DFISSIPVDY IFLIVETRID SDFYKTARAL RIVRFTKILS
LLRLLRLSRL IRYIHQWEEI FHMTYDLASA MVRIVNLIGM MLLLCHWDGC LQFLVPMLQD
FPADCWVSKN KMVNDTWGQQ YSYALFKAMS HMLCIGYGMY PPVGMTDVWL TILSMIVGAT
CYAMFVGHAT ALIQSLDSSR RQYQEKYKQV EQYMSFHKLP ADMRQRIHDY YEHRYQGKMF
DEESILGELN EPLREEIINF NCRKLVASMP LFANADPNFV TSMLTKLKFE VFQPRDYIIR
EGTIGKKMYF IQHGVVSVLT KGSKETKLSD GSYFGEICLL TRGRRTASVR ADTYCRLYSL
SVDNFNEVLE EYPMMRRAFE TVALDRLDRI GKKNSILQHK VQHDLSSGVL NYQENEIIQQ
IVQHDRDMAH CAHLLQNAPP RTPPSPTPVI WAPLIQAPLQ AAAATTSVAI ALTHHPHFPP
TLFRPPVSVL GSLKDPSSHL KKFHTYVPPA SGSTGDSPCS TPSKLSTGVD MPLLATFRAQ
HMTSGTGATG SSLQASGSGG KHGPSGAGSG SSGGGTFPSG QYSSSGSPSS SMAQLHPQPQ
HQQPFRSSTP PLSKIFHQGS ISGSTGSGIG GGAIGACGGA TGWSSAGAAG GSVEGATGED
AAWAGEDFTT GTTEVTPGVN FGLGGATCGL VGEISGESTG GVSEGSVAAA CGRLVSGASG
VSVGSITLGQ TGDVTRRSMT GTYKGSLKRA SRGSVGGASG ESLVVTTTGG SLGRASIGSL
GVVSGGLTGG ASGGSLVRTS GDSMVGNSGA SLGRASVGST SSHIGGASIG QGVGVIGGHV
SRAVGGAVGS HIGGPATCPA GGSSGGITSG FINSSHCHSP ISTSSSSPMP GQLLHSQPPP
KPPQLSPLQQ FAGGGRTTSG LNLFNTPPQG SPSLSRGQHS QQPAEGSVSS LSHFSLPGLP
SGFLPHQVSL ERSALASLAQ YGSANASPCL TPIAPSPTIQ SPVAGRTFHY SDPSSAMGSH
SSLFMPQSYL PSQLPGQPQT TGRDSPLGRF SEDLRLLSSS PPPLHQEVAH ALGHHTPPPS
VETGYYPSPF SSPTLVPKPC SSVPGRMTPP IQTSPGHPHQ TRPPGTSPAL HLRRGSAAYS
SDLEPQTVRS KLPSNL
//
